Most ebook files are in PDF format, so you can easily read them using various software such as Foxit Reader or directly on the Google Chrome browser.
Some ebook files are released by publishers in other formats such as .awz, .mobi, .epub, .fb2, etc. You may need to install specific software to read these formats on mobile/PC, such as Calibre.
Please read the tutorial at this link: https://ebookbell.com/faq
We offer FREE conversion to the popular formats you request; however, this may take some time. Therefore, right after payment, please email us, and we will try to provide the service as quickly as possible.
For some exceptional file formats or broken links (if any), please refrain from opening any disputes. Instead, email us first, and we will try to assist within a maximum of 6 hours.
EbookBell Team
5.0
108 reviewsSUMMARYThe metabolic stress occurring in the tumor microenvironment (TME) hampers T cell anti-tumor immunity bydisturbing T cell metabolic and epigenetic programs. Recent studies are making headway toward identifyingstrategies to unleash T cell activities by targeting T cell metabolism. Furthermore, efforts have been made toimprove the efficacy of immune checkpoint blockade and adoptive cell transfer therapies. However, distincttreatment outcomes across different cancers raise the question of whether our understanding of the featuresof CD8+ T cells within the TME are universal, regardless of their tissue of origin. Here, we review the commonand distinct environmental factors affecting CD8+ T cells across tumors. Moreover, we discuss how distincttissue-specific niches are interpreted by CD8+ T cells based on studies on tissue-resident memory T (Trm)cells and how these insights can pave the way for a better understanding of the metabolic regulation ofCD8+ T cell differentiation and anti-tumor immunity.
