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52 reviewsCONTEXT AND SIGNIFICANCE The multimorbidity pattern of metabolic dysfunction-associated steatoticliver disease (MASLD) remains underexplored. Here, researchers performed a comprehensive explorationof the health impacts associated with MAFLD. Our findings reveal MASLD’s significant impact not only onliver health but also as a significant contributor to elevated risk of all-cause mortality and 96 comorbiditiesacross digestive, circulatory, metabolic, genitourinary, neurological, gastrointestinal, and hematologic systems. Sequential patterns of MASLD-related extrahepatic comorbidities were identified, particularly in circulatory, metabolic, and inflammatory diseases. This study highlights MASLD’s extensive health consequencesand underscores the importance of targeted strategies to disrupt the pathways linking MASLD to variousdownstream diseases in affected individuals.
