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4.3
8 reviewsgenetics, offering a unique perspective on how gene expression in the brain is
dynamically regulated without altering the underlying DNA sequence.
Neuroepigenetic Mechanisms in Health and Disease aims to provide a comprehen-
sive overview of the fundamental epigenetic processes that govern brain function
and their role in a range of physiological and pathological conditions.
The book opens with Chap. 1, which establishes the foundational concepts of
epigenetics, exploring how histone modifications, DNA methylation, and transcrip-
tion factors regulate gene expression in the 3,000 diverse cell types of the human
brain. This chapter underscores the importance of epigenetic mechanisms in main-
taining the functional integrity of the genome.
