Obesity and Metabolism 1st Edition by Marta Korbonits ISBN 9783805584296 by M. Korbonits 9783805584296, 3805584296 instant download after payment.

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ISBN 13: 9783805584296
Author: Marta Korbonits

Obesity and Metabolism 1st Table of contents:

• Part 1: Genetics of Obesity

  • Monogenic Human Obesity:
    • Discussion of single gene defects that cause severe obesity (e.g., mutations in leptin, leptin receptor, MC4R, POMC pathways).
    • Clinical characteristics and treatment implications of these rare forms.
  • Polygenic Contribution to Obesity:
    • The role of multiple genes interacting with environmental factors.
    • Genetic susceptibility and predisposition.
    • Genome-wide association studies (GWAS) and their findings.

• Part 2: Hormones and Biochemical Regulation of Metabolism

  • Leptin and Adiponectin in Obesity:
    • The role of these key adipokines in energy balance, appetite regulation, and insulin sensitivity.
    • Leptin resistance in common obesity.
  • Ghrelin and Other Gut Peptides:
    • The role of orexigenic (appetite-stimulating) and anorexigenic (appetite-suppressing) gut hormones.
    • Pyy, GLP-1, oxyntomodulin, etc., and their therapeutic potential.
  • Insulin and Insulin Resistance:
    • Mechanisms of insulin resistance in obesity.
    • Its link to metabolic syndrome and Type 2 diabetes.
  • Thyroid Hormones and Metabolism:
    • The impact of thyroid function on metabolic rate and body weight.
  • Steroid Hormones (e.g., Cortisol, Sex Hormones) and Obesity:
    • The role of glucocorticoids in fat distribution and metabolic dysfunction.
    • Sex differences in obesity and fat metabolism.
  • Other Hormones and Enzymes Implicated in Obesity Development and Maintenance:
    • Exploring newly identified hormonal or enzymatic players in energy homeostasis.

• Part 3: Obesity Across the Lifespan and Specific Populations

  • Developmental Origins of Obesity and Metabolic Syndrome:
    • The fetal programming concept (Barker Hypothesis).
    • Maternal nutrition, perinatal environment, and long-term obesity risk in offspring.
  • Childhood and Adolescent Obesity:
    • Prevalence, causes, and unique challenges in pediatric obesity.
    • Early intervention strategies.
  • Obesity in Pregnancy:
    • Impact of maternal obesity on pregnancy outcomes for mother and child.
    • Gestational diabetes and other complications.
  • Obesity in Old Age:
    • Sarcopenic obesity and its implications.
    • Metabolic changes in aging.

• Part 4: Clinical Approaches and Treatment of Obesity

  • Assessment and Diagnosis of Obesity:
    • BMI, waist circumference, body composition analysis.
    • Comprehensive clinical evaluation.
  • Lifestyle Interventions:
    • Dietary strategies (e.g., low-carb, low-fat, Mediterranean).
    • Physical activity and exercise recommendations.
    • Behavioral therapy.
  • Pharmacological Treatment of Obesity:
    • Review of approved anti-obesity medications (at the time of publication).
    • Mechanisms of action, efficacy, and side effects.
  • Bariatric and Metabolic Surgery:
    • Types of surgical procedures (gastric bypass, sleeve gastrectomy, etc.).
    • Mechanisms of weight loss and metabolic improvement.
    • Outcomes and complications.

• Part 5: Social and Broader Perspectives

  • Social Aspects of Obesity:
    • Stigma, discrimination, and psychological impact.
    • Public health approaches and policy.
  • The Obese Body in Art Throughout the Centuries:
    • A unique chapter exploring cultural perceptions of body weight over time.

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Tags: Marta Korbonits, Obesity, Metabolism