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Optimised Medical Therapy Alone Versus Optimised Medical Therapy Plus Revascularisation For Asymptomatic Or Lowtointermediate Risk Symptomatic Carotid Stenosis Ecst2 2year Interim Results Of A Multicentre Randomised Trial Simone J A Donners

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Optimised Medical Therapy Alone Versus Optimised Medical Therapy Plus Revascularisation For Asymptomatic Or Lowtointermediate Risk Symptomatic Carotid Stenosis Ecst2 2year Interim Results Of A Multicentre Randomised Trial Simone J A Donners
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Optimised Medical Therapy Alone Versus Optimised Medical Therapy Plus Revascularisation For Asymptomatic Or Lowtointermediate Risk Symptomatic Carotid Stenosis Ecst2 2year Interim Results Of A Multicentre Randomised Trial Simone J A Donners instant download after payment.

Publisher: x
File Extension: PDF
File size: 1.88 MB
Author: Simone J A Donners, Twan J van Velzen, Suk Fun Cheng, John Gregson, Audinga-Dea Hazewinkel, Francesca B Pizzini, Bart J Emmer,
ISBN: 101016/S14744422(25)001073
Language: English
Year: 2025

Product desciption

Optimised Medical Therapy Alone Versus Optimised Medical Therapy Plus Revascularisation For Asymptomatic Or Lowtointermediate Risk Symptomatic Carotid Stenosis Ecst2 2year Interim Results Of A Multicentre Randomised Trial Simone J A Donners by Simone J A Donners, Twan J Van Velzen, Suk Fun Cheng, John Gregson, Audinga-dea Hazewinkel, Francesca B Pizzini, Bart J Emmer, 101016/S14744422(25)001073 instant download after payment.

The Lancet Neurology, 24 (2025) 389-399. doi:10.1016/S1474-4422(25)00107-3

SummaryBackground Carotid revascularisation, comprising either carotid endarterectomy or stenting, is offered to patients Lancet Neurol 2025; 24: 389–99with carotid stenosis to prevent stroke based on the results of randomised trials conducted more than 30 years ago. See Comment page 372Since then, medical therapy for stroke prevention has improved. We aimed to assess whether patients with *Contributed equallyasymptomatic and symptomatic carotid stenosis with a low or intermediate predicted risk of stroke, who received †ECST-2 investigators are listed optimised medical therapy (OMT), would benefit from additional revascularisation.in the appendix (pp 2–3)Department of Vascular Methods The Second European Carotid Surgery Trial (ECST-2) is a muloutcome adjudication, which was conducted at 30 centres with stroke anEurope and Canada. Patients aged 18 years or older with asymptomatic or greater, and a 5-year predicted risk of ipsilateral stroke of less than 20% (e[CAR] score), were recruited. Patients were randomly assigned to eithelarisation (1:1) using a web-based system. The primary outcome for this 2-youtcome composite of: (1) periprocedural death, fatal stroke, or fatal myo(3) non-fatal myocardial infarction; or (4) new silent cerebral infarction ontreat using the win ratio—ie, each patient in the OMT alone group was comOMT plus revascularisation group, with a win declared for the patient withwas declared if neither patient in the pair had a better outcome). The win ratin the OMT alone group divided by the number of wins in the OMT pluregistered with the ISRCTN Registry (ISRCTN97744893) and is ongoing.