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0 reviewsOvercoming Steroid Insensitivity in Respiratory Disease reviews important new advances in therapeutics and provides the clinician with the most up to date information on one of the most significant therapeutic challenges to effective management of these diseases. This unique book is an invaluable resource for all postgraduate students and specialist physicians in pulmonology allergy and asthma. It is also of interest for workers in biomedical and pharmaceutical research.Content:
Chapter 1 Molecular Mechanisms of Glucocorticoid Receptor Action (pages 1–18): Pankaj Bhavsar and Ian M. Adcock
Chapter 2 Side Effects of Topical and Oral Glucocorticoids (pages 19–38): Heike Schacke, Khusru Asadullah and Wolf?Dietrich Docke
Chapter 3 Glucocorticoid Receptor Subtypes and Steroid Sensitivity (pages 39–54): Robert H. Oakley and John A. Cidlowski
Chapter 4 Dissociated Glucocorticoids (pages 55–71): Ian M. Adcock
Chapter 5 Generalized Glucocorticoid Insensitivity: Clinical Phenotype and Molecular Mechanisms (pages 73–87): Evangelia Charmandari, Tomoshige Kino and George P. Chrousos
Chapter 6 Corticosteroid Responsiveness in Asthma: Clinical Aspects (pages 89–107): Kian Fan Chung
Chapter 7 Glucocorticoid?Insensitive Asthma: Molecular Mechanisms (pages 109–124): John W. Bloom
Chapter 8 Cigarette Smoke, Oxidative Stress and Corticosteroid Responsiveness (pages 125–144): Irfan Rahman and David Adenuga
Chapter 9 Regulation of Glucocorticoid Sensitivity by Macrophage Migration Inhibitory Factor (pages 145–161): Eric F. Morand
Chapter 10 Steroid?Sparing Strategies: Long?Acting Inhaled ?2?Agonists (pages 163–185): Anna Miller?Larsson and Olof Selroos
Chapter 11 Steroid?Sparing Strategies: Other Combinations (pages 187–206): Gaetano Caramori, Kazuhiro Ito and Alberto Papi
Chapter 12 Kinases as Anti?Inflammatory Targets for Respiratory Disease (pages 207–241): Iain Kilty
Chapter 13 Pharmacokinetic/Pharmacodynamic Factors and Steroid Sensitivity (pages 243–262): Gonther Hochhaus
Chapter 14 Improved Lung Deposition: New Inhaler Devices (pages 263–281): Omar S. Usmani
