Overweight and the Metabolic Syndrome From Bench to Bedside Endocrine Updates 1st Edition by George A Bray, Louisiana State University Pennington Biomedical Research Cent ISBN 0387321632 9780387321639 by George A. Bray, Louisiana State University 0387321632 instant download after payment.

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ISBN 10: 0387321632 
ISBN 13: 9780387321639
Author: George A Bray, Louisiana State University Pennington Biomedical Research Cent

Overweight and the Metabolic Syndrome will provide an overview of topics related to obesity, including associated health risks, childhood obesity, genetics, evaluation, treatment, behavioral strategies, and successes and failures in preventing obesity.

The body composition that underlies obesity and the metabolic syndrome is key to understanding the problem. The mechanisms by which energy balance is maintained is key to how the problem goes wrong. The metabolic syndrome is in part a consequence of central fat storage, but includes more issues such as insulin resistance, low levels of inflammation, and endothelial dysfunction. This volume will cover evaluation guidelines, different approaches to treatment, including diet, exercise, behavior, drugs, and surgery to deal with the current world-wide obesity epidemic.

Overweight and the Metabolic Syndrome From Bench to Bedside Endocrine Updates 1st Table of contents:

Part I: Basic Science Foundations (Bench)

• Chapter 1: Neuroendocrine Control of Food Intake
  • Regulation of appetite and satiety
  • Role of hormones (leptin, ghrelin, insulin, PYY, GLP-1, etc.)
  • Brain regions involved in energy homeostasis
  • Neurotransmitters and their pathways
• Chapter 2: Current Views of the Fat Cell as an Endocrine Cell: Adipokines and Lipotoxicity
  • Adipose tissue as an active endocrine organ
  • Key adipokines (adiponectin, resistin, TNF-α, IL-6)
  • Role of inflammation in obesity
  • Lipotoxicity and its impact on various organs (liver, muscle, pancreas)
• Chapter 3: Ectopic Fat and Metabolic Syndrome
  • Definition and significance of ectopic fat deposition (visceral, liver, muscle)
  • Mechanisms by which ectopic fat contributes to insulin resistance and metabolic dysfunction
  • Measurement of ectopic fat
• Chapter 4: Genetics of Overweight and Obesity
  • Heritability of obesity
  • Monogenic and polygenic forms of obesity
  • Gene-environment interactions
  • Genetic susceptibility to metabolic syndrome components
• Chapter 5: The Gut Microbiome and Metabolic Health
  • Role of gut bacteria in energy metabolism
  • Impact of diet on microbiome composition
  • Connections to obesity and insulin resistance

Part II: Clinical Evaluation and Diagnosis (Bedside)

• Chapter 6: Body Composition Assessment of Obesity
  • Methods for measuring body fat (BMI, waist circumference, DEXA, bioimpedance, etc.)
  • Clinical utility and limitations of different methods
  • Importance of visceral fat assessment
• Chapter 7: Defining and Diagnosing the Metabolic Syndrome
  • Evolution of diagnostic criteria (WHO, NCEP ATP III, IDF, AHA/NHLBI)
  • Clinical significance of the diagnosis
  • Risk stratification
• Chapter 8: Overweight and Metabolic Syndrome in Childhood and Adolescence
  • Prevalence and trends in pediatric obesity
  • Diagnostic considerations in children
  • Long-term health consequences
  • Prevention and early intervention strategies

Part III: Clinical Management and Treatment (Bedside)

• Chapter 9: Lifestyle Interventions: Diet and Nutrition Strategies
  • Principles of energy balance
  • Different dietary approaches for weight loss and metabolic health (low-carb, low-fat, Mediterranean, DASH)
  • Role of macronutrient composition
• Chapter 10: Lifestyle Interventions: Physical Activity and Exercise
  • Benefits of exercise for weight management and metabolic syndrome
  • Types of exercise and recommended guidelines
  • Behavioral strategies to promote physical activity
• Chapter 11: Behavioral Strategies for Weight Management
  • Cognitive behavioral therapy (CBT) for obesity
  • Motivational interviewing
  • Self-monitoring and goal setting
  • Long-term maintenance strategies
• Chapter 12: Pharmacotherapy for Overweight and Obesity
  • Current FDA-approved medications for weight loss
  • Mechanisms of action, efficacy, and side effects
  • Considerations for long-term use
• Chapter 13: Bariatric Surgery for Severe Obesity and Metabolic Syndrome
  • Indications and contraindications for bariatric surgery
  • Types of bariatric procedures (Roux-en-Y gastric bypass, sleeve gastrectomy, adjustable gastric band)
  • Mechanisms of weight loss and metabolic improvement
  • Pre- and post-operative care and complications
• Chapter 14: Prevention of Overweight and Metabolic Syndrome
  • Public health approaches to obesity prevention
  • Community-based interventions
  • Policy changes and environmental factors

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Tags: George A Bray, Louisiana State University Pennington Biomedical Research Cent, Overweight, Metabolic