Pain Current Understanding Emerging Therapies and Novel Approaches to Drug Discovery 1st Edition by Chas Bountra ISBN 0824788656 9780824788650 by Chas Bountra, Rajesh Munglani, William K. Schmidt 0824788656, 9780824788650 instant download after payment.

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ISBN 10: 0824788656 
ISBN 13: 9780824788650
Author: Chas Bountra

This reference presents a detailed overview of approaches and techniques in the management of pain caused by tissue, nerve and central nervous system injuries, categorizing pain into a variety of syndromes and underlying mechanisms to aid the development of interventional pharmacologic measures.

Pain Current Understanding Emerging Therapies and Novel Approaches to Drug Discovery 1st Table of contents:

1 Mechanism-Based Classifications of Pain and Analgesic Drug Discovery
2 Sites of Analgesie Action
3 From Acute to Chronic Pain
4 Central and Peripheral Components of Neuropathic Pain
5 A New Perspective on Signal Transduction in Neuropathic Pain
6 Pain and the Somatosensory Cortex
7 Descending Pathways in Spinal Cord Stimulation and Pain Control
8 Local Neuroimmune Interactions in Visceral Hyperalgesia
9 Pain Processing in the Periphery
10 Neuroimaging of Pain
11 Surrogate Models of Pain
12 Acute Trauma and Postoperative Pain
13 Effectiveness of Needling Techniques with Special Reference to Myofascial Pain Syndromes
14 Advances in the Management of Spinal Pain and Radiofrequency Techniques
15 Pulsed Radiofrequency Treatment of Chronic Neck, Back, Sympathetic, and Peripheral Neuroma-Derived Pain
16 Spinal Cord Stimulation
17 Spinal Endoscopy
18 Cancer Pain Treatment
19 Inflammatory Joint Disease and Pain
20 Chronic Nonmalignant Visceral Pain Syndromes of the Abdomen, Pelvis, and Bladder and Chronic Urogenital and Rectal Pain
21 Nerve Injury Pain
22 Sympathetically Maintained Pain
23 Headache
24 Psychological Factors in Measurement of Pain
25 Challenges and Pitfalls of Clinical Trials
26 Molecular Approaches to the Study of Pain
27 Molecular Validation of Pain Targets
28 Genetics of Pain
29 Animal Models of Pain
30 An Overview of Current and Investigational Drugs for the Treatment of Acute and Chronic Pain
31 Novel Mu, Delta, and Kappa Agonists
32 Delta-Receptor, Nonpeptide Agonists
33 Peripheral Opioid Analgesia
34 Profile of ADL 2-1294, an Opioid Antihyperalgesic Agent with Selectivity for Peripheral Mu-Opiate Receptors
35 Controlled-Release Opioids
36 NMDA-Receptor Antagonists as Enhancers of Analgesic Activity
37 CCK Antagonist Potentiation of Opioid Analgesia
38 Profile of NSAID + Opioid Combination Analgesics
39 NSAIDs and COX-2 Inhibitors
40 COX-2-Specific Inhibitors
41 NK! Receptor Antagonists
42 Vanilloids
43 The Development of Bradykinin Antagonists as Therapeutic Agents
44 The Treatment of Neuropathic Pain
45 /V-Methyl-D-Aspartate (NMDA) Receptors as a Target for Pain Therapy
46 Profile of Ketamine, CPP, Dextromethorphan, and Memantine
47 GV 196771 A, a New Glycine Site Antagonist of the NMD A Receptor with Potent Antihyperalgesic Activity
48 Voltage-Gated Sodium Channels and Pain
49 Calcium Channel Antagonists and the Control of Pain
50 Profile of Ziconotide (SNX-111) A Neuronal N-Type Voltage-Sensitive Calcium Channel Blocker
51 Nitric Oxide Synthase Inhibitors and the Role oí Nitric Oxide in Nociception
52 Adenosine and Pain
53 Adenosine Kinase Inhibition as a Therapeutic Approach to Analgesia
54 P2X Purinergic Receptors for ATP in Nociception
55 Somatostatin Receptors in Analgesia
56 Cannabinoids
57 Antinociceptive Effects of Centrally Administered Neurotrophic Factors
58 Peripheral Neurotrophic Factors and Pain
59 Profile of Tramadol and Tramadol Analogues
60 Sumatriptan and Related 5-HT1b/id Receptor Agonists
61 Cholinergic Approaches to Pain Therapy
62 Analgesic Effects of Vedaclidine, a Mixed Agonist-Antagonist at Muscarinic Receptor Subtypes
63 Gabapentin and Related Compounds
64 The Role of Gabapentin in the Management of Neuropathic Pain
65 New Local Anesthetic Analgesics
66 Spinal a2-Ädrenergic Agonists for Intractable Cancer Pain
67 Cellular Implantation for the Treatment of Chronic Pain
68 Bone-Seeking Radiopharmaceuticals to Palliate Painful Bone Metastases

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