Pharmacogenetics And Individualized Therapy Ankehilse Maitlandvan Der Zee by Anke-hilse Maitland-van Der Zee, Ann K. Daly 9780470433546, 9781118116494, 047043354X, 1118116496 instant download after payment.

This resource provides thorough coverage of pharmacogenetics and its impact on pharmaceuticals, therapeutics, and clinical practice. It opens with the basics of pharmacogenetics, including drug disposition and pharmacodynamics. The following section moves into specific disease areas, including cardiovascular, psychiatry, cancer, asthma/COPD, adverse drug reactions, transplantation, inflammatory bowel disease, and pain medication. Clinical practice and ethical issues make up the third section, with the fourth devoted to technologies like genotyping, genomics, and proteomics. In the fifth part, chapters discuss the impact of key regulatory issues on the pharmaceutical industry.Content:
Chapter 1 Pharmacogenetics: A Historical Perspective (pages 1–12): Ann K. Daly
Chapter 2 Pharmacogenetics in Drug Metabolism: Role of Phase I Enzymes (pages 13–80): Vita Dolzan
Chapter 3 Pharmacogenetics of Phase II Drug Metabolizing Enzymes (pages 81–100): Ingolf Cascorbi
Chapter 4 Pharmacogenetics of Drug Transporters (pages 101–148): Henriette E. Meyer zu Schwabedissen, Markus Grube and Heyo K. Kroemer
Chapter 5 Pharmacogenetics of Drug Targets (pages 149–182): Ann K. Daly and Maria Arranz
Chapter 6 Cardiovascular Pharmacogenetics (pages 183–213): Bas J. M. Peters, Anthonius de Boer, Tom Schalekamp, Olaf H. Klungel and Anke?Hilse Maitland?van der Zee
Chapter 7 Pharmacogenetics in Psychiatry (pages 215–250): Evangelia M. Tsapakis, Sarah Curran, Ruth I. Ohlsen, Nora S. Vyas, Katherine J. Aitchison and Ann K. Daly
Chapter 8 Pharmacogenetics in Cancer (pages 251–270): Sharon Marsh
Chapter 9 Pharmacogenetics of Asthma and COPD (pages 271–294): Ellen S. Koster, Jan A. M. Raaijmakers, Anke?Hilse Maitland?van der Zee and Gerard H. Koppelman
Chapter 10 Pharmacogenetics of Adverse Drug Reactions (pages 295–321): Ann K. Daly, Martin Armstrong and Munir Pirmohamed
Chapter 11 Pharmacogenomics of Inflammatory Bowel Diseases (pages 323–351): Alexander Teml, Susanne Karner, Elke Schaeffeler and Matthias Schwab
Chapter 12 Pharmacogenetics of Pain Medication (pages 353–374): Jorn Lotsch
Chapter 13 Ethical and Social Issues in Pharmacogenomics Testing (pages 375–400): Susanne Vijverberg, Toine Pieters and Martina Cornel
Chapter 14 High?Throughput Genotyping Technologies for Pharmacogenetics (pages 401–414): Beatriz Sobrino and Angel Carracedo
Chapter 15 Developments in Analyses in Pharmacogenetic Datasets (pages 415–435): Alison A. Motsinger?Reif
Chapter 16 Applications of Pharmacogenetics in Pharmaceutical Research and Development (pages 437–460): Daniel K. Burns and Scott S. Sundseth
Chapter 17 Role of Pharmacogenetics in Registration Processes (pages 461–475): Myong?Jin Kim, Issam Zineh, Shiew?Mei Huang and Lawrence J. Lesko
Chapter 18 Pharmacogenetics: Possibilities and Pitfalls (pages 477–483): Anke?hilse Maitland?van der Zee and Ann K. Daly