Phase Of Firing Does Not Reflect Temporal Order In Sequence Memory Of Humans And Recurrent Neural Networks Stefanie Liebe Johannes Niediek Matthijs Pals Thomas P Reber Jennifer Faber Jan Bostrampx000f6m Christian E Elger Jakob H Macke Florian Mormann by Stefanie Liebe & Johannes Niediek & Matthijs Pals & Thomas P. Reber & Jennifer Faber & Jan Bostramp#x000f6;m & Christian E. Elger & Jakob H. Macke & Florian Mormann 101038/S41593025018937 instant download after payment.

The temporal order of a sequence of events has been thought to be refected in the ordered fring of neurons at diferent phases of theta oscillations. Here we assess this by measuring single neuron activity (1,420 neurons) and local feld potentials (921 channels) in the medial temporal lobe of 16 patients with epilepsy performing a working-memory task for temporal order. During memory maintenance, we observe theta oscillations, preferential fring of single neurons to theta phase and a close relationship between phase of fring and item position. However, the fring order did not match item order. Training recurrent neural networks to perform an analogous task, we also show the generation of theta oscillations, theta phase-dependent fring related to item position and, again, no match between fring and item order. Rather, our results suggest a mechanistic link between phase order, stimulus timing and oscillation frequency. In both biological and artifcial neural networks, we provide evidence supporting the role of phase of fring in working-memory processing.