Developed under the guidance of Dr. Dwight Burlingame of the Indiana University Center on Philanthropy, one of the nation's premier institutes for the study of philanthropy, the three-volume Philanthropy in America: A Comprehensive Historical Encyclopedia is the definitive work on philanthropic, charitable, and nonprofit endeavors in the United States. The first section of the encyclopedia contains over 200 A–Z entries covering the lives of important philanthropists, the missions and practices of key institutions and organizations, and the impact of seminal events throughout the history of the nonprofit sector in America, from precolonial times to the present.

Discussions of philanthropic traditions in ancient civilizations, in Europe during colonial times, and in countries around the world today provide fascinating contexts for understanding how the American philanthropic experience has developed. The encyclopedia also includes a collection of primary source documents (legislation, foundation reports, mission statements, etc.) for convenient review and further research.