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Photoreceptors and Calcium Advances in Experimental Medicine and Biology Book 514 1st Edition by Wolfgang Baehr, Krzysztof Palczewski 978-1461501213

SKU: BELL-2261088

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Photoreceptors and Calcium Advances in Experimental Medicine and Biology Book 514 1st Edition by Wolfgang Baehr, Krzysztof Palczewski 978-1461501213 instant download after payment.

Publisher: Springer US

File Extension: PDF

File size: 8.17 MB

Pages: 625

Author: Kei Nakatani, Chunhe Chen, King-Wai Yau, Yiannis Koutalos (auth.), Wolfgang Baehr Ph.D., Krzysztof Palczewski Ph.D. (eds.)

ISBN: 0306474158

Language: English

Year: 2002

Edition: 1

Product desciption

Photoreceptors and Calcium Advances in Experimental Medicine and Biology Book 514 1st Edition by Wolfgang Baehr, Krzysztof Palczewski 978-1461501213 by Kei Nakatani, Chunhe Chen, King-wai Yau, Yiannis Koutalos (auth.), Wolfgang Baehr Ph.d., Krzysztof Palczewski Ph.d. (eds.) 0306474158 instant download after payment.

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ISBN 13: 978-1461501213

Author: Wolfgang Baehr, Krzysztof Palczewski

2 The role of Ca+ as an internal messenger in visual transduction of vertebrate and invertebrate organisms has been explored intensely in the recent past. Since the 2 early 1970s, calcium ions and cyclic GMP (whose
levels are controlled by Ca+ in vertebrates) have been recognized as important second messengers. Particularly in 2 the last decade, however, the role of Ca+ in visual transduction has been re-evalu ated and a proliferation
of research has documented a multiplicity of roles. 2 It is now evident that Ca+ modulates phototransduction by acting at several 2 sites through a host of small Ca+ -binding proteins. For example, in phototransduction 2 of
vertebrates, Ca+-free forms of guanylate cyclase activating proteins (GCAPs) activate guanylate cyclase, modulating levels of cOMP, a key event in the return of photoreceptors to pre-bleach conditions. Defects in genes
encoding guanylate cy clase or guanylate cyclase activating proteins lead to severe diseases of the retina (e. g. , Leber congenital amaurosis, rod/cone dystrophy, or cone dystrophy), thus em phasizing the important role of
these proteins in phototransduction. Similarly, mu 2 tant genes encoding cation or Ca+ channels (cyclic nucleotide-gated cation chan 2 nels located in the cell membrane and L-type voltage-gated Ca+ channels located at the
synapse of photo receptors) lead to retinitis pigmentosa or congenital stationary night blindness. In phototransduction of invertebrate organisms (e. g. , Drosophila 2 and Limulus), the role of Ca+ is similarly central, but
distinct, from that of vertebrates.

Calcium and Phototransduction
The Calcium Gradient Along The Rod Outer Segment
The Time Course of Light Adaptation in Vertebrate Retinal Rods
S-Modulin
Ca2+-Dependent Control of Rhodopsin Phosphorylation: Recoverin And Rhodopsin Kinase
Recoverin And Rhodopsin Kinase
Pathological Roles Of Recoverin In Cancer-Associated Retinopathy
Rgs9-1 Phosphorylation And Ca2+
Phosphorylation by Cyclin-Dependent Protein Kinase 5 Of The Regulatory Subunit (Pγ) Of Retinal cGMP Phosphodiesterase (PDE6): Its Implications In Phototransduction
Centrins, A Novel Group Of Cat2,2+-Binding Proteins In Vertebrate Photoreceptor Cells
Tuning Outer Segment Ca2+Homeostasis to Phototransduction in Rods and Cones
Regulation of the Rod Photoreceptor Cyclic Nucleotide-Gated Channel
Ca2+-Channels in the RPE
The Retinal Rod and Cone Na+/Ca2+-K+Exchangers
The Complex of cGMP-Gated Channel and Na+/ Ca2+K+Exchanger in Rod Photoreceptors
Regulation of Voltage-Sensitive Ca2+ Channels in Bipolar Cells by Divalent Cations and Polyamines
Site-Directed and Natural Mutations in Studying Functional Domains in Guanylyl Cyclase Activating Proteins (GCAPs)
Calmodulin And Ca2+-Binding Proteins (CaBPs): Variations on a Theme
GCAPs: Ca2+-Sensitive Regulators of retGC
Structure and Membrane-Targeting Mechanism of Retinal Ca2+-Binding Proteins, Recoverin and GCAP-2
Target Recognition of Guanylate Cyclase By Guanylate Cyclase-Activating Proteins
Mouse Models to Study GCAP Functions In Intact Photoreceptors
Calcium-Dependent Activation of Guanylate Cyclase by S100b
The Role of Cadherins in Ca2+-Mediated Cell Adhesion and Inherited Photoreceptor Degeneration
Guanylate Cyclase Activating Proteins, Guanylate Cyclase and Disease
Using Mutant Mice to Study the Role of Voltage-Gated Calcium Channels in the Retina
Caldendrins in the Inner Retina
Calcium Channels at the Photoreceptor Synapse
On Bipolar Cells: Following in the Footsteps of Phototransduction
Ca2+ Regulation of Drosophila Phototransduction
Simultaneous Roles for Ca2+ in Excitation and Adaptation of Limulus Ventral Photoreceptors
Calcium Homeostasis in Fly Photoreceptor Cells
Photoreceptor Degeneration and Ca2+ Influx Through Light-Activated Channels of Drosophila
The TRP Calcium Channel and Retinal Degeneration