Plasmid Biopharmaceuticals Basics Applications And Manufacturing Duarte Miguel F Prazeresauth by Duarte Miguel F. Prazeres(auth.) 9780470232927, 9780470939918, 0470232927, 0470939915 instant download after payment.

The book addresses the basics, applications, and manufacturing of plasmid biopharmaceuticals. The survey of the most relevant characteristics of plasmids provides the basics for designing plasmid products (applications) and processes (manufacturing). Key features that the authors include in the book are: i) consistency and clear line of direction, ii) an extensive use of cross-referencing between the individual chapters, iii) a rational integration of chapters, iv) appellative figures, tables and schemes, and v) an updated, but selected choice of references, with a focus on key papers.Content:
Chapter 1 Historical Perspective (pages 1–34):
Chapter 2 Gene Transfer with Plasmid Biopharmaceuticals (pages 35–68):
Chapter 3 Product and Process Development (pages 69–84):
Chapter 4 Structure (pages 85–128):
Chapter 5 Analytical Characterization (pages 129–165):
Chapter 6 Delivery (pages 167–210):
Chapter 7 Ethical and Safety Issues (pages 211–242):
Chapter 8 Human and Veterinary Markets (pages 243–271):
Chapter 9 Human Case Studies: Pandemic Influenza and Critical Limb Ischemia (pages 273–300):
Chapter 10 Veterinary Case Studies: West Nile, Infectious Hematopoietic Necrosis, and Melanoma (pages 301–325):
Chapter 11 Good Manufacturing Practice and Validation (pages 327–355):
Chapter 12 Product Specifications and Quality Control (pages 357–390):
Chapter 13 Cell Culture (pages 391–414):
Chapter 14 An Overview of Downstream Processing (pages 415–425):
Chapter 15 Primary Isolation (pages 427–453):
Chapter 16 Intermediate Recovery (pages 455–495):
Chapter 17 Final Purification (pages 497–542):
Chapter 18 Process Synthesis (pages 543–562):
Chapter 19 Concluding Remarks and Outlook (pages 563–578):