Plateletderived Growth Factor B Attenuates Lethal Sepsis Through Inhibition Of Inflammatory Responses Min Wang Jilou Wei Futai Shang Kui Zang Ting Ji by Min Wang & Jilou Wei & Futai Shang & Kui Zang & Ting Ji instant download after payment.

ABSTRACTKeywords:Sepsis is a systemic inflammatory response during infection and remains a major clinical problem with highPlatelet-derived growth factor Bmorbidity and mortality. Platelet-derived growth factor B (PDGF-B) is a member belongs to PDGF family and hasSepsisbeen recently reported higher expressed in survivors of severe sepsis patients. However, the exact role andInflammatory cytokinesunderlying mechanisms of PDGF-BB in sepsis remains unclear. In this study, we found that PDGF-BB levels wereChemokinessignificantly elevated in patients with sepsis, and higher PDGF-BB levels were negatively correlated with thelevels of proinflammatory cytokines (TNF-α, IL-6, IL-1β, IL-8), and chemokines (CXCL-1 and CCL2). PDGF-BBwas also found increased in experimental sepsis in mice. Blockade of PDGF-BB using Tyrphostin AG 1296 aggravated, whereas recombinant PDGF-BB treatment improved survival and tissues injury in both two murinemodels of CLP-induced sepsis and LPS- induced endotoxemia. PDGF-BB blockade increased, whereas PDGF-BBadministration decreased the inflammatory responses, as reflected by proinflammatory cytokines (TNF-α, IL-6,IL-1β, IL-8), and chemokines (CXCL-1 and CCL2). PDGF-BB also showed inhibitory effect on immune cell activation and cytokines production in vivo and in vitro. Therefore, our findings suggest that PDGF-BB plays aprotective role in sepsis by decreasing the production of pro-inflammatory cytokines and chemokines. PDGF-BBthus may be a potential therapeutic strategy for treating sepsis.