Pre Eclampsia prevention prediction and possibilities 1st Edition by Pankaj Desai ISBN 0367135078 9780367135072 by Desai, Pankaj 9780367086046, 9780367135072, 9780429023286, 0367086042, 0367135078, 0429023286 instant download after payment.

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ISBN 10: 0367135078 
ISBN 13: 9780367135072
Author: Pankaj Desai

Pre-eclampsia, a complication of pregnancy characterized by hypertension and/or edema and/or proteinuria, can have profound effects on the mother as well as the unborn fetus and even threaten their lives. Pre-eclampsia: Prevention, Prediction and Possibilities discusses the possible causes of the condition, its effects on various body systems, current methods of prediction, prevention, and treatment. What makes this book unique is its coverage of the deep intricacies of what causes Pre-eclampsia from examining the role of genetics and exosomes to lipids and their denaturation to endothelial denaturation and reperfusion damage. These extremely complex processes are thoroughly examined and then explained in a simplified way to enhance understanding. The latest concepts in color Doppler in prediction and current measures of prevention and treatment are explained at length. Overall, Pre-eclampsia will provide an updated resource for practicing obstetricians, research scientists, students and professionals involved in the care of pregnant subjects. Key Features Presents the etiopathology of Pre-eclampsia with recent research updates Establishes the link between Pre-eclampsia and other obstetric vasculopathies Covers individual systemic effects of the condition Explores the latest approach in prediction, prevention and treatment of Pre-eclampsia About the Author Dr. Pankaj Desai is a Consultant Obstetrics and Gynecology Specialist at Janani Maternity Hospital, Baroda, India. A prolific writer, he has contributed 43 chapters to different textbooks internationally and nationally. His outstanding academic contributions in the subject have been acknowledged and honored with 7 gold medals and 60 orations.

Pre Eclampsia prevention prediction and possibilities 1st Table of contents:

Part 1 General aspects of pre-eclampsia
1 Introduction
General aspects of pre-eclampsia
What is pre-eclampsia?
What is obstetric vasculopathy?
Part 2 Possibilities in Aetiology of pre-eclampsia
2 Immunology of pre-eclampsia
Immune tolerance and pre-eclampsia
Types of pre-eclampsia based on immunology
First few days of placentation and pre-eclampsia
The autonomous tight unit
Uterine glands and placentation
Uterine milk
Uterine gland knockout cells
The crosstalk
References
3 Endothelial cell dysfunction and pre-eclampsia
Introduction
The phenomenon of endothelial cell activation
Circulating markers of endothelial activation
Endothelial activation and prostaglandins
Plasminogen and allied procoagulant activity: A manifestation of endothelial cell activation
Antiphospholipid antibodies act through procoagulant mechanism
Endothelial cell adhesion molecule disturbances
VEGF
Clinical bearings
Endothelin
Other molecules contributing to endothelial cell activation
Immunological antibodies
Cytokines
Formed elements in blood
“Toxins”
List of Abbreviations
References
4 Oxidative stress and pre-eclampsia
Introduction
What is oxidative stress?
What is a free radical?
Oxygen: A double-edged sword
The mischief of free radicals in vascular walls
Lipid peroxides: The agents of oxidative stress
Our basic study
Lipid metabolism in normal pregnancy and in pre-eclampsia
Hypertriglyceridemia and pre-eclampsia
Small dense LDL phenotype in pre-eclampsia
Placental lipid peroxidation
Transition metals in lipid peroxidation
Clinical manifestations
Reperfusion
Innate maternal reducing systems
The family of free radicals
Vascular endothelium and oxidative stress
Inefficient second wave of trophoblastic invasion
Production of vascular endothelial growth factors
Nitric oxide in pre-eclampsia
Nitric oxide and endothelial cells
Placental atherosis in pre-eclampsia
Extracellular reducing systems
Uric acid: The powerhouse reductant
Policeman-to-riot model to understand uric acid
Limitations of reducing systems
Inconsistency of reducing systems
The ideal reducing system
Exercise and prevention of pre-eclampsia
The beauty of lysophosphotidyl choline
References
5 Metabolic syndrome and pre-eclampsia
What is metabolic syndrome?
Metabolic syndrome and hypertension
Metabolic changes in normal pregnancy
Basal metabolic rate
Proteins and amino acids
Carbohydrates
Lipids
Diagnosis of metabolic syndrome
Metabolic syndrome and pre-eclampsia
References
6 The genetics of pre-eclampsia
Basis for reviewing the role of genetics in pre-eclampsia
Challenges to the genetic studies in pre-eclampsia
Mammalian studies
Application of genetic models
Examining associations
Foetal contributions: Any?
Immunology and genetics
Epigenetics and pre-eclampsia
References
Part 3 Prediction
7 Prediction of pre-eclampsia
Introduction
Challenges to tests for prediction in pre-eclampsia
Need for multiple tests
Assessing the quality of tests in prediction of pre-eclampsia
Overview of the types of tests
Clinical bearings of negative and positive tests
An ideal test
Clinical tests
Mid-trimester blood pressure
The roll-over test
Hand-grip test
Maternal weight gain in pregnancy
Urinary tests
Microalbuminuria
Urinary calcium
Calcium-to-creatinine ratio
Kallikrein
Haematological indices
Cellular components in prediction of pre-eclampsia
Leucocytes
Platelets and platelet activation
Uric acid
Fibronectin
β-hCG
Epidemiological indices in pre-eclampsia prediction
Colour Doppler in pre-eclampsia prediction: The game changer
Review of indices
Doppler indices with biomarkers
The diastolic notch
What is diastolic notch?
Practical problem with using colour Doppler and biomarker in combination
Notch Depth Index
Doppler indices for the discontinuation of preventive measures
Identifying low-risk subjects in the first trimester
The future: Nanoparticles including exosomes
References
Part 4 Prevention
8 Prevention of pre-eclampsia
Introduction
What is the difference between disease and derangement?
Which subjects may benefit?
Salt restriction
Diuretics
Antihypertensives
Calcium supplementation
Other trace elements and micronutrients
Aspirin for the prevention of pre-eclampsia
Possible mechanism of action of aspirin
Aspirin: Review of literature
What dose of aspirin: 75 mg or 150 mg?
Misgivings and fears about aspirin
Aspirin timing
References
Part 5 Systemic Manifestations
9 Central nervous system
Changes in the CNS
Pathological lesions in pre-eclampsia
Brain
Posterior leukoencephalopathy syndrome
Psychiatric complications following obstetric vasculopathies: Any correlation?
References
10 Cardiovascular system
Changes in cardiac functions
Stroke volume and heart rate
How does the heart increase its cardiac output?
Vascular response to increase cardiac output
Oscillatory pressure and propulsive pressure
Peripheral vascular resistance
Changes in venous system
References
11 Haematological system
Introduction
Alteration in coagulation factors (other than platelets) and procoagulants
Alteration in other cellular components of blood
Review of coagulation alterations in pre-eclampsia
Platelets in normal and pre-eclamptic pregnancies
Concept of competence alteration (efficiency) of platelets
Platelet activation and thromboxane A2 production
References
12 Hepatobiliary system
Introduction
Pathological changes in the liver
Liver in the HELLP syndrome
References
13 Ophthalmie system
Introduction
The peripheral pathogenesis of ophthalmic changes in pre-eclampsia
The central pathogenesis of ophthalmic changes in pre-eclampsia
Visual alterations of special mention – recurrent and unilateral
References
14 Renal system
Introduction
Brief outline of renal changes in pregnancy
Vulnerability of renal system
Special features of renal failure complicating pre-eclampsia
Renal lesions
Are kidney changes in pre-eclampsia – pathognomonic?
Gross changes in the kidneys
On microscopy
Renal function alterations in pre-eclampsia
Renal handling of proteins in pre-eclampsia
Handling of urinary excretion of proteins in pre-eclampsia
Renin-angiotensin system in pre-eclampsia
References
Part 6 Clinical features of pre-eclampsia
15 Clinieal features
Introduction
Classification
Hypertension
Proteinuria
Oedema
Grades of severity of pre-eclampsia
References
Part 7 Treatment of pre-eclampsia
16 Treatment of pre-eclampsia
Introduction
Management goals in pre-eclampsia
Early diagnosis and alert surveillance
Do women with pre-eclampsia need admission?
Management on hospitalization
Antihypertensives
Does mild pre-eclampsia need antihypertensives?
Challenges before treating pre-eclampsia with antihypertensives
Which antihypertensive?
Mono therapy versus multi-drug therapy
Drugs and their dosage schedules
When to stop antihypertensives
Induction of labour in PIH
37 weeks
Induction of labour in eclampsia
Induction of labour in severe pre-eclampsia
Induction of labour in pregnancy for foetal reasons
Case study in CPR
Analysis of the case study
The need for involving a neonatologist

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