Progress in Medicinal Chemistry 40 1st Edition by F D King, A W Oxford ISBN 0444510540 9780444510549 by F.d. King, A.w. Oxford, Allen B. Reitz And Scott L. Dax (eds.) 0444510540, 9780444510549 instant download after payment.

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ISBN 10: 0444510540 
ISBN 13: 9780444510549
Author: F D King, A W Oxford

Progress in Medicinal Chemistry 40 1st Table of contents:

• Chapter 1: The Discovery and Development of Atorvastatin, a Potent Novel Hypolipidemic Agent
  • This chapter would cover the chemical synthesis, biological activity, structure-activity relationships, and clinical development of atorvastatin (Lipitor), a highly successful statin drug for lowering cholesterol.
• Chapter 2: Discovery of CEP-1347/KT-7515, an Inhibitor of the JNK/SAPK Pathway for the Treatment of Neurodegenerative Diseases
  • This would detail the research and development of a specific small molecule inhibitor targeting the c-Jun N-terminal kinase (JNK) / stress-activated protein kinase (SAPK) pathway, exploring its potential therapeutic applications for conditions like Parkinson's or Alzheimer's.
• Chapter 3: Discovery of Second Generation Quinazolinone Non-Nucleoside Reverse Transcriptase Inhibitors of HIV-1
  • This chapter would focus on the design, synthesis, and biological evaluation of a class of anti-HIV drugs (NNRTIs), specifically the quinazolinone derivatives, aiming to overcome resistance issues associated with first-generation drugs.
• Chapter 4: Molecular Modeling of Opioid Receptor-Ligand Complexes
  • This would delve into the computational chemistry aspects of understanding how opioid drugs interact with their receptors at a molecular level, likely using techniques like molecular docking, QSAR, and molecular dynamics simulations to guide drug design.

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