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RAS Family GTPases Proteins and Cell Regulation 1st Edition by Channing Der 1402043287 978-1402043284

  • SKU: BELL-2008692
RAS Family GTPases Proteins and Cell Regulation 1st Edition by Channing Der 1402043287 978-1402043284
$ 31.00 $ 45.00 (-31%)

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RAS Family GTPases Proteins and Cell Regulation 1st Edition by Channing Der 1402043287 978-1402043284 instant download after payment.

Publisher: Springer
File Extension: PDF
File size: 5.48 MB
Pages: 396
Author: C Der (Ed.)
ISBN: 9781402043284, 9781402047084, 1402043287, 1402047088
Language: English
Year: 2006
Edition: 1

Product desciption

RAS Family GTPases Proteins and Cell Regulation 1st Edition by Channing Der 1402043287 978-1402043284 by C Der (ed.) 9781402043284, 9781402047084, 1402043287, 1402047088 instant download after payment.

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Product details:

ISBN 10: 1402043287

ISBN 13: 978-1402043284

Author: Channing Der

Since 1982, Ras proteins have been the subject of intense research investigation by the biomedical research community. The wide interest in Ras has been stimulated for three key reasons.

First, their frequent mutational activation in human cancers establishes Ras proteins as important mediators of oncogenesis and targets for anti-cancer drug discovery. Second, Ras proteins act as signalling nodes activated by diverse extracellular stimuli, and activated Ras in turn regulates a diversity of cytoplasmic signalling networks. Third, Ras proteins are founding members of a large superfamily of Ras-related small GTPases. Over 150 Ras-related small GTPases are found in the human genome, with orthologs found in all vertebrate species and invertebrates.

This book features chapters by leading investigators in the field that highlight the current state-of-the art in Ras biochemistry, structure and biology. This book is an excellent reference for students in the biomedical sciences and for investigators in the field.

Table of contents:

  1. Ras Stories: The State of the Art

  2. Ras-GEFs and Ras GAPs

  3. Structural Principles of Ras Interaction with Regulators and Effectors

  4. Ras and the Raf/MEK/ERK Cascade

  5. Noncanonical Effector Targets of Oncogenic Ras Proteins

  6. Effectors of Ras-Mediated Oncogenesis

  7. RHO Proteins in RAS Signaling and Transformation

  8. Global Effects of Ras Signaling on the Genetic Program in Mammalian Cells

  9. Ras Signaling in C. elegans

  10. Ras Family G-Proteins in Saccharomyces cerevisiae and Schizosaccharomyces pombe

  11. Comparison of the Effects of Ras Effector Mutants and Ras Effectors on Transformed and Tumorigenic Growth of Human and Rodent Cells

  12. Genetically Engineered Mice Harboring Ras Mutations as Models of Human Cancer: In Medias Ras

  13. Ras Family Proteins

  14. kB-Ras: A Small GTPase that Influences NF-κB Signaling

  15. ANTI-Ras Strategies for Cancer Treatment

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Tags: Channing Der, Family, GTPases, Proteins

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