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Resolving The Cholesterol Controversy The Scientists Who Proved The Lipid Hypothesis Of Causation Of Atherosclerosis And Coronary Heart Disease Gilbert R Thompson

  • SKU: BELL-51392434
Resolving The Cholesterol Controversy The Scientists Who Proved The Lipid Hypothesis Of Causation Of Atherosclerosis And Coronary Heart Disease Gilbert R Thompson
$ 31.00 $ 45.00 (-31%)

4.7

26 reviews

Resolving The Cholesterol Controversy The Scientists Who Proved The Lipid Hypothesis Of Causation Of Atherosclerosis And Coronary Heart Disease Gilbert R Thompson instant download after payment.

Publisher: WSPC (EUROPE)
File Extension: PDF
File size: 60.67 MB
Pages: 246
Author: Gilbert R Thompson
ISBN: 9781800613973, 1800613970
Language: English
Year: 2023

Product desciption

Resolving The Cholesterol Controversy The Scientists Who Proved The Lipid Hypothesis Of Causation Of Atherosclerosis And Coronary Heart Disease Gilbert R Thompson by Gilbert R Thompson 9781800613973, 1800613970 instant download after payment.

Resolving the Cholesterol Controversy recounts the science and scientific personalities behind the chain of discoveries upon which the lipid hypothesis of atherosclerosis was built. The narrative covers a period of just under 100 years, starting with Anitschkow's experiments with cholesterol-fed rabbits in 1913, and recounts the endeavours and achievements of the leading actors in this protracted scientific drama. The cast is drawn from an extraordinary variety of scientific disciplines: pathology, biophysics, epidemiology, nutrition, cardiology, lipidology, genetics, microbiology, pharmacology, and clinical trial design. Most of the scientists believed that cholesterol played a causal role in atherosclerosis and cardiovascular disease, but there were some who dissented strongly from this conclusion. The breadth of scientific disciplines involved in proving the lipid hypothesis is matched by the geographical spread of the participants. Anitschkow worked in Russia, Endo discovered the first statin in Japan, their commercial development by Merck took place in the USA and evidence of benefit from lowering cholesterol came from trials conducted in Scandinavia and the UK. The subsequent meta-analysis of these statin trials in 2005 proved the validity of the lipid hypothesis beyond any doubt. The history of how this all came about and its impact upon health policy and medical practice is recalled here in Resolving the Cholesterol Controversy.

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