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Retrotransposons And Human Disease L1 Retrotransposons As A Source Of Genetic Diversity Abram Gabriel

Name: Retrotransposons And Human Disease L1 Retrotransposons As A Source Of Genetic Diversity Abram Gabriel
SKU: BELL-47291304
Price: 31.00 USD
Availability: InStock
Rating: 4 (56 reviews)

SKU: BELL-47291304

$ 31.00 ~~$ 45.00~~ (-31%)

4.0

56 reviews

Retrotransposons And Human Disease L1 Retrotransposons As A Source Of Genetic Diversity Abram Gabriel instant download after payment.

Publisher: World Scientific Publishing

File Extension: PDF

File size: 18.09 MB

Pages: 260

Author: Abram Gabriel

ISBN: 9789811249211, 9811249210

Language: English

Year: 2022

Product desciption

Retrotransposons And Human Disease L1 Retrotransposons As A Source Of Genetic Diversity Abram Gabriel by Abram Gabriel 9789811249211, 9811249210 instant download after payment.

Thirty years ago we knew that retrotransposons made up at least half of our genomes, but little about their role in biology. The human genome has since been sequenced and the position of all retrotransposons in the reference sequence has been determined. However, as of today, the function of retrotransposons still remains elusive. We know much more about the diseases associated with their movement and the host defenses we all have against them. This volume explores an array of diseases in humans associated with L1 retrotransposon movement within the human genome, including some cancers such as colon cancer and neuropsychiatric disorders such as schizophrenia. The chapters explore the diversity of retrotransposons, their different biological mechanisms, the role of L1 in their movement, and their contribution to human diseases. This book posits that somatic events caused by retrotransposons have implications for mosaicism and are often associated with cancers. Germline events are common, occur quite early in development, and are a cause of single gene diseases. All in all, the authors implicate L1 retrotransposons as major sources of human diversity and advocate for their continued study.