Ribozymes Principles Methods Applications Sabine Müller Benoït Masquida Wade Winkler by Sabine Müller; Benoït Masquida; Wade Winkler 9783527814534, 3527814531 instant download after payment.

This all-encompassing reference on ribozymes integrates the knowledge that has gained in the field over the past 35 years, with contributions by virtually all leading experts in the field. Organized six major parts, it describes general principles and strategies of nucleic acid catalysis, introduces naturally occurring ribozymes including the search for new catalytic motifs or novel genomic locations of known motifs, followed by an extensive section on ribozyme engineering and artificial ribozymes. The fourth part covers DNAzymes, their development and potential application. The design of ribozymes and DNAzymes for medical diagnostics and as therapeutic tools is covered in part 5. The final part looks at tools and methods in ribozyme research, including the techniques and assays for structural and functional characterization of nucleic acid catalysts.