Role of Proteases in the Pathophysiology of Neurodegenerative Diseases 2001st Edition by Herman Friedman, Allen Honeyman, Able Lajtha, Lynda J Katz ISBN 9780306468476 by A Lajtha, Nl Banik (eds.) 0306465795, 9780306465796 instant download after payment.

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ISBN 13: 9780306468476
Author: Herman Friedman, Allen Honeyman, Able Lajtha, Lynda J Katz

Role of Proteases in the Pathophysiology of Neurodegenerative Diseases 2001st Table of contents:

I. Introduction to Proteases and Neurodegeneration

• General overview of proteases and their classification
• Introduction to neurodegenerative diseases and their common features
• The general concept of protein turnover and degradation in the nervous system

II. Major Protease Systems in the Brain

• The Ubiquitin-Proteasome Pathway (UPP):
  • Mechanism and components of the UPP
  • Role of UPP in protein quality control
  • Dysfunction of UPP in neurodegenerative disorders (e.g., accumulation of ubiquitinated proteins)
• Lysosomal Proteases (Cathepsins):
  • Overview of cathepsins (e.g., cathepsin D, B, L)
  • Role of lysosomes in cellular degradation (autophagy-lysosome pathway)
  • Implications of lysosomal dysfunction in neurodegeneration
• Calcium-Activated Neutral Proteinases (Calpains):
  • Characteristics and regulation of calpains
  • Role of calpains in neuronal injury and death
  • Calpain involvement in specific neurodegenerative diseases
• Caspases:
  • Role of caspases in apoptosis (programmed cell death)
  • Caspase activation in neurodegenerative conditions
  • Caspase-mediated neuronal damage

III. Proteases in Specific Neurodegenerative Diseases

• Alzheimer's Disease:
  • Amyloid Precursor Protein (APP) processing by secretases (α, β, γ-secretases)
  • Role of BACE (Beta-site APP cleaving enzyme) and presenilins
  • Tau protein pathology and protease involvement
• Parkinson's Disease:
  • Alpha-synuclein aggregation and degradation pathways
  • Role of proteases in Lewy body formation
• Huntington's Disease and Polyglutamine Disorders:
  • Proteolytic processing of mutant huntingtin and other polyQ proteins
  • Implications for protein aggregation and toxicity
• Amyotrophic Lateral Sclerosis (ALS):
  • Role of proteases in motor neuron degeneration
  • Involvement of UPP and other pathways
• Autoimmune Demyelinating Diseases (e.g., Multiple Sclerosis):
  • Role of proteolytic enzymes in demyelination
  • Matrix metalloproteinases (MMPs) and their impact
• Cerebral Ischemia and Traumatic Brain/Spinal Cord Injury:
  • Acute protease activation following injury
  • Role of calpains and other proteases in secondary damage

IV. Therapeutic Approaches Targeting Proteases

• Protease inhibitors as potential therapeutic agents
• Strategies for enhancing protein clearance pathways (e.g., modulating UPP or autophagy)
• Challenges and future directions in protease-targeted therapies

V. Emerging Concepts and Future Directions

• Novel proteases implicated in neurodegeneration
• Cross-talk between different proteolytic systems
• Genetic factors and protease activity
• Biomarkers and diagnostic applications

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Tags: Herman Friedman, Allen Honeyman, Able Lajtha, Lynda J Katz, Role, Pathophysiology