Selective Presynaptic Inhibition Of Leg Proprioception In Behaving Drosophila Chris J Dallmann Yichen Luo Sweta Agrawal Akira Mamiya Grant M Chou Andrew Cook Anne Sustar Bingni W Brunton John C Tuthill by Chris J. Dallmann & Yichen Luo & Sweta Agrawal & Akira Mamiya & Grant M. Chou & Andrew Cook & Anne Sustar & Bingni W. Brunton & John C. Tuthill instant download after payment.

Controlling arms and legs requires feedback from the proprioceptive sensory neurons that detect joint position and movement1,2. Proprioceptive feedback must be tuned for diferent behavioural contexts3–6, but the underlying circuit mechanisms remain poorly understood. Here, using calcium imaging in behaving Drosophila, we fnd that the axons of position-encoding leg proprioceptors are active across a range of behaviours, whereas the axons of movement-encoding leg proprioceptors are suppressed during walking and grooming. Using connectomics7–9, we identify a specifc class of interneurons that provide GABAergic presynaptic inhibition to the axons of movement-encoding proprioceptors. These interneurons receive input from parallel excitatory and inhibitory descending pathways that are positioned to drive the interneurons in a context-specifc and leg-specifc manner. Calcium imaging from both the interneurons and their descending inputs confrms that their activity is correlated with self-generated but not passive leg movements. Taken together, our fndings reveal a neural circuit that suppresses specifc proprioceptive feedback signals during self-generated movements.