Self Perpetuating Structural States in Biology Disease and Genetics 1st Edition by Susan Lindquist, Steve Henikoff 030957045X 9780309570459 by Proceedings Of The National Academy Of Sciences 9780309084451, 9780309570459, 0309084458, 030957045X instant download after payment.

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ISBN 10: 030957045X

ISBN 13: 9780309570459

Author: Susan Lindquist, Steve Henikoff

Over the past half-century, the central dogma, in which DNA makes RNA makes protein, has dominated thinking in biology, with continuing refinements in understanding of DNA inheritance, gene expression, and macromolecular interactions. However, we have also witnessed the elucidation of epigenetic phenomena that violate conventional notions of inheritance. Protein-only inheritance involves the transmission of phenotypes by self-perpetuating changes in protein conformation. Proteins that constitute chromatin can also transmit heritable information, for example, via posttranslational modifications of histones. Both the transmission of phenotypes via the formation of protein conformations and the inheritance of chromatin states involve self-perpetuating assemblies of proteins, and there is evidence for some common structural features and conceptual frameworks between them. To foster interactions between researchers in these two fields, the National Academy of Sciences convened an Arthur M. Sackler Colloquium entitled'Self-Perpetuating Structural States in Biology, Disease, and Genetics'in Washington, DC, on March 22-24, 2002. Participants described new phenomenology and provided insights into fundamental mechanisms of protein and chromatin inheritance. Perhaps most surprising to attendees was emerging evidence that these unconventional modes of inheritance may be common.

Table of contents:

1. Self-perpetuating structural states in biology, disease, and genetics

2. Transmission of prions

3. Conservation of a portion of the S. cerevisiae Ure2p prion domain that interacts with the full-length protein

4. Interactions among prions and prion “strains” in yeast

5. Identification of benzothiazoles as potential polyglutamine aggregation inhibitors of Huntington's disease by using an automated filter retardation assay

6. Chaperoning brain degeneration

7. Molecular chaperones as modulators of polyglutamine protein aggregation and toxicity

8. Studies of the aggregation of mutant proteins in vitro provide insights into the genetics of amyloid diseases

9. Sequence-dependent denaturation energetics: A major determinant in amyloid disease diversity

10. The insulation of genes from external enhancers and silencing chromatin

11. Histone H3 lysine 4 methylation is mediated by Set1 and promotes maintenance of active chromatin states in fission yeast

12. Changes in the middle region of Sup35 profoundly alter the nature of epigenetic inheritance for the yeast prion [PSI+]

13. Heritable chromatin structure: Mapping “memory” in histones H3 and H4

14. Does heterochromatin protein 1 always follow code?

15. Self-perpetuating epigenetic pili switches in bacteria

16. Histone H3 variants specify modes of chromatin assembly

17. Induction and maintenance of nonsymmetrical DNA methylation in Neurospora

18. Locus-specific control of asymmetric and CpNpG methylation by the DRM and CMT3 methyltransferase genes

19. RNA-directed DNA methylation in Arabidopsis

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Tags: Susan Lindquist, Steve Henikoff, Perpetuating, Structural