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Target Validation In Drug Discovery 1st Edition Brian W Metcalf

  • SKU: BELL-2401512
Target Validation In Drug Discovery 1st Edition Brian W Metcalf
$ 31.00 $ 45.00 (-31%)

4.8

64 reviews

Target Validation In Drug Discovery 1st Edition Brian W Metcalf instant download after payment.

Publisher: Academic Press
File Extension: PDF
File size: 2.11 MB
Pages: 293
Author: Brian W. Metcalf, Susan Dillon
ISBN: 9780123693938, 0123693934
Language: English
Year: 2006
Edition: 1

Product desciption

Target Validation In Drug Discovery 1st Edition Brian W Metcalf by Brian W. Metcalf, Susan Dillon 9780123693938, 0123693934 instant download after payment.

This work presents a comprehensive contemporary framework for approaching target validation in drug discovery. It begins with a detailed description of new enabling technologies, including aptamers, RNA interference, functional genomics, and proteomics. The next section looks at biologic drug development with in-depth discussion of lessons learned from such well-known cases as Erbitux, Herceptin, and Avastin. Additional targets known as "second generation" drugs, which can be identified when disease pathways are validated by biologics, present new possible small molecule therapeutics and serve as the focus of the final section of the book.

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