The Encyclopedia of Parkinson s Disease 2nd Edition by Anthony D Mosley, Deborah S Romaine, M D Samii, Ali ISBN 081607674X 9780816076741 by Anthony D. Mosley, Deborah S. Romaine, Ali Samii 081607674X instant download after payment.

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ISBN 10: 081607674X 
ISBN 13: 9780816076741
Author: Anthony D Mosley, Deborah S Romaine, M D Samii, Ali

Each year about half a million Americans are diagnosed with Parkinson's disease, with about 1.2 million people in the United States and Canada currently suffering from it. This chronic neurological disorder appears most commonly in people age 50 and over, though recent trends have shown the disease developing more often in those age 40 and under. Recent developments in Parkinson's disease research and the completion of the Human Genome Project have led to a better understanding of the role of genetics in causing Parkinson's disease.

Since publication of the first edition of The Encyclopedia of Parkinson's Disease, several studies have concluded, new studies have begun, and treatment approaches and recommendations have changed. Updated to reflect the latest research and trends in diagnosing and treating this disorder, this revised edition presents more than 650 entries explaining the complex issues and topics related to Parkinson's, including etiology, surgeries, research, medical terms, and much more. New information has been added on deep brain stimulation therapy, dopaminergic cell replacement, dopamine agonist therapy, breakthroughs in understanding the etiology and epidemiology of Parkinson's disease, and many other topics. Appendixes include a directory of organizations and resources as well as a directory of state Medicaid offices.

The Encyclopedia of Parkinson s Disease 2nd Table of contents:

Part I: The Science of Parkinson's Disease

• A-Z Entries on Biological and Neurological Concepts
  • Alpha-synuclein: The protein at the core of Lewy bodies.
  • Basal Ganglia: The brain region affected by PD.
  • Dopamine: The key neurotransmitter involved.
  • Genetics of Parkinson's Disease: A review of common genetic mutations (e.g., LRRK2, PINK1, GBA).
  • Lewy Bodies: The hallmark protein aggregates in the brain.
  • Mitochondrial Dysfunction: The role of cellular energy problems.
  • Neurodegeneration: The process of nerve cell death.
  • Substantia Nigra: The dopamine-producing area of the brain.

Part II: Symptoms, Signs, and Diagnosis

• A-Z Entries on Clinical Manifestations and Diagnostic Procedures
  • Bradykinesia: Slowness of movement.
  • Clinical Diagnostic Criteria: How doctors confirm a diagnosis.
  • Cognitive Changes: Thinking and memory issues.
  • Dysphagia: Swallowing difficulties.
  • Dysarthria: Speech problems.
  • Fatigue: A common non-motor symptom.
  • Gait and Balance Issues: Shuffling gait and postural instability.
  • Motor Symptoms: The classic "cardinal" symptoms.
  • Non-Motor Symptoms: A wide range of non-movement-related symptoms (e.g., constipation, sleep disorders, anxiety).
  • Prodromal Symptoms: Early signs before motor symptoms appear.
  • Rigidity: Muscle stiffness.
  • Tremor: The characteristic resting tremor.

Part III: Treatments and Management

• A-Z Entries on Medications, Therapies, and Surgical Options
  • Apomorphine: A fast-acting dopamine agonist.
  • Carbidopa/Levodopa: The "gold standard" medication.
  • COMT Inhibitors: Medications to extend levodopa's effect.
  • Deep Brain Stimulation (DBS): A surgical treatment.
  • Dopamine Agonists: Medications that mimic dopamine's effects.
  • Exercise: The critical role of physical activity.
  • Levodopa-Induced Dyskinesia (LID): Involuntary movements from medication.
  • MAO-B Inhibitors: Medications that prevent dopamine breakdown.
  • Occupational Therapy: Adapting to daily challenges.
  • Physical Therapy: Improving mobility and balance.
  • Speech and Swallowing Therapy: Addressing communication and eating difficulties.

Part IV: Research and Future Directions

• A-Z Entries on Ongoing Research and Emerging Treatments
  • Biomarkers: Finding indicators for early diagnosis.
  • Clinical Trials: How new therapies are tested.
  • Gene Therapy: A potential future treatment.
  • Neuroprotection: Protecting neurons from damage.
  • Stem Cell Research: Replacing damaged dopamine-producing cells.
  • Therapeutic Vaccines: Targeting alpha-synuclein.

Part V: Living with Parkinson's

• A-Z Entries on Daily Life, Social, and Emotional Aspects
  • Advanced Parkinson's: Managing later-stage symptoms.
  • Caregivers: The essential role of family and friends.
  • Diet and Nutrition: The importance of a balanced diet.
  • Dystonia: Painful muscle contractions.
  • Hallucinations and Psychosis: Managing mental health symptoms.
  • Mental Health: Addressing depression and anxiety.
  • Sleep Disorders: Insomnia and restless legs syndrome.
  • Support Groups: Finding community and resources.

Part VI: Related Conditions and Concepts

• A-Z Entries on Atypical Parkinsonisms and Related Disorders
  • Corticobasal Degeneration (CBD)
  • Dementia with Lewy Bodies (DLB)
  • Multiple System Atrophy (MSA)
  • Parkinsonism: A general term for PD-like symptoms.
  • Progressive Supranuclear Palsy (PSP)
  • Vascular Parkinsonism

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