The Growth Hormone Insulin Like Growth Factor Axis During Development 1st Edition by Isabel Varela Nieto, Julie Ann Chowen ISBN 1461498112 9781461498117 by Laura M. Frago, Julie A. Chowen (auth.), Isabel Varela-nieto Phd, Julie A. Chowen Phd (eds.) 9780387251196, 9780387262741 instant download after payment.

The Growth Hormone Insulin Like Growth Factor Axis During Development 1st Edition by Varela Nieto, Julie Ann Chowen - Ebook PDF Instant Download/Delivery: 1461498112, 9781461498117
Full download The Growth Hormone Insulin Like Growth Factor Axis During Development 1st Edition after payment

Product details:

ISBN 10: 1461498112 
ISBN 13: 9781461498117
Author:  Varela Nieto, Julie Ann Chowen

The Growth Hormone Insulin Like Growth Factor Axis During Development 1st Table of contents:

Part I: Fundamental Biology of the GH/IGF Axis

• Chapter 1: Introduction to the Growth Hormone/Insulin-Like Growth Factor Axis
  • Overview of the GH-IGF-1 system: components and functions.
  • Historical perspective on the discovery and understanding of GH and IGFs.
  • Key terminology and definitions.
• Chapter 2: Growth Hormone (GH): Synthesis, Secretion, and Regulation
  • Pituitary gland and somatotrophs.
  • Hypothalamic control: GHRH and Somatostatin.
  • Ghrelin and other regulatory factors.
  • Pulsatile secretion patterns and their significance.
• Chapter 3: Insulin-Like Growth Factors (IGFs): IGF-1 and IGF-2
  • Structure, synthesis (primarily hepatic, but also local production).
  • Receptors: IGF-1R, IGF-2R, insulin receptor.
  • Signaling pathways (e.g., PI3K/Akt, MAPK).
• Chapter 4: IGF-Binding Proteins (IGFBPs) and Their Role
  • Overview of the six main IGFBPs and their characteristics.
  • Regulation of IGF bioavailability and action.
  • Proteolysis of IGFBPs.

Part II: The GH/IGF Axis Across Developmental Stages

• Chapter 5: Embryonic and Fetal Development
  • Role of IGF-2 and IGF-1 in early embryonic growth.
  • Placental involvement and maternal-fetal interactions.
  • Genetic imprinting and IGF-2.
  • Consequences of dysregulation (e.g., IUGR, overgrowth syndromes).
• Chapter 6: Postnatal Growth and Infancy
  • Transition from prenatal to postnatal growth regulation.
  • Nutritional influences on the GH/IGF axis.
  • Role in organ development and maturation.
• Chapter 7: Childhood and Puberty
  • GH and IGF-1 as primary drivers of linear growth.
  • Pubertal growth spurt and hormonal interactions (sex steroids).
  • Disorders of growth: Growth hormone deficiency, Laron syndrome, IGF-1 deficiency.
  • Genetic and environmental factors influencing growth.
• Chapter 8: Adolescence and Transition to Adulthood
  • Epiphyseal fusion and cessation of linear growth.
  • Continued role of GH/IGF-1 in body composition, bone mass, and metabolism.
  • Maturation of the GH/IGF axis.

Part III: Clinical Aspects and Pathophysiology

• Chapter 9: Disorders of GH/IGF Axis Excess in Development
  • Pituitary gigantism: Etiology, diagnosis, and treatment.
  • Other causes of overgrowth (e.g., Sotos syndrome, Beckwith-Wiedemann syndrome).
• Chapter 10: Disorders of GH/IGF Axis Deficiency in Development
  • Isolated Growth Hormone Deficiency (IGHD) vs. Combined Pituitary Hormone Deficiency (CPHD).
  • Diagnosis and challenges in pediatric GHD.
  • Recombinant human GH (rhGH) therapy: indications, efficacy, and safety.
  • Primary IGF-1 deficiency and Laron Syndrome.
• Chapter 11: Resistance to GH or IGF-1 Action
  • GH receptor mutations.
  • Post-receptor defects.
  • Clinical implications.
• Chapter 12: The GH/IGF Axis and Specific Organ Development/Function
  • Bone and cartilage development.
  • Muscle growth and metabolism.
  • Brain development and neuroendocrine functions.
  • Cardiovascular system.
  • Renal function.
• Chapter 13: Nutritional Aspects and Metabolic Regulation
  • Impact of malnutrition (over- and under-nutrition) on the axis.
  • Role in glucose metabolism and insulin sensitivity.
  • Obesity and the GH/IGF axis.

Part IV: Future Directions and Therapeutic Frontiers

• Chapter 14: Emerging Therapies and Diagnostics
  • Novel approaches to stimulate/inhibit the GH/IGF axis.
  • Advanced diagnostic tools.
• Chapter 15: Genetic Basis of GH/IGF Axis Disorders
  • Next-generation sequencing and discovery of new genes.
  • Pharmacogenomics in GH therapy.
• Chapter 16: Long-Term Outcomes of Early GH/IGF Dysregulation
  • Adult health implications of childhood growth disorders.
  • Metabolic syndrome, cardiovascular risk, bone health.

People also search for The Growth Hormone Insulin Like Growth Factor Axis During Development 1st:

the growth hormone insulin like growth
    
insulin like growth factor growth hormone
    
insulin-like growth factors
    
insulin is a growth hormone
    
growth hormone insulin like growth factor axis

Tags: Varela Nieto, Julie Ann Chowen, Hormone, Insulin