The Molecular Mechanism And Therapeutic Landscape Of Copper And Cuproptosis In Cancer Ziyu Guo Danyao Chen Lei Yao Yuming Sun Daishi Li Jiayuan Le Yating Dian Furong Zeng Xiang Chen Guangtong Deng by Ziyu Guo & Danyao Chen & Lei Yao & Yuming Sun & Daishi Li & Jiayuan Le & Yating Dian & Furong Zeng & Xiang Chen & Guangtong Deng 101038/S41392025021920 instant download after payment.

Copper, an essential micronutrient, plays significant roles in numerous biological functions. Recent studies have identifiedimbalances in copper homeostasis across various cancers, along with the emergence of cuproptosis, a novel copper-dependentform of cell death that is crucial for tumor suppression and therapeutic resistance. As a result, manipulating copper levels hasgarnered increasing interest as an innovative approach to cancer therapy. In this review, we first delineate copper homeostasis atboth cellular and systemic levels, clarifying copper’s protumorigenic and antitumorigenic functions in cancer. We then outline thekey milestones and molecular mechanisms of cuproptosis, including both mitochondria-dependent and independent pathways.Next, we explore the roles of cuproptosis in cancer biology, as well as the interactions mediated by cuproptosis between cancercells and the immune system. We also summarize emerging therapeutic opportunities targeting copper and discuss the clinicalassociations of cuproptosis-related genes. Finally, we examine potential biomarkers for cuproptosis and put forward the existing1234567890();,:challenges and future prospects for leveraging cuproptosisthe molecular mechanisms and therapeutic landscape of copcuproptosis-based therapies for cancer treatment.