The Vascular Contribution To Cognitive Decline In Ageing And Dementia Silvia Anderle Michael Dixon Tania Quintelalopez George Siderislampretsas David Attwell by Silvia Anderle & Michael Dixon & Tania Quintela-lopez & George Sideris-lampretsas & David Attwell instant download after payment.

There is increasing evidence to suggest that vascular dysfunction Introductioncan contribute to cognitive decline in ageing and dementia. This Mechanisms generating a fall dysfunction can take the form of a reduction of cerebral blood fow in CBF(CBF), a loss of blood–brain barrier (BBB) function or a combination CBF changes in normal ageingof the two. Indeed, CBF and BBB changes may be causally linked, CBF changes in ADalthough this possible causality and its directionality are understudied. CBF changes in VaDAppreciation of the role of vascular dysfunction in initiating cognitive Future directionsdecline in ageing and dementia, as well as the mechanisms involved, is important because it opens up new avenues for the development of much-needed therapies for these conditions, which are becoming major causes of death. Here we assess the evidence for the importance of vascular contributions to dementia, draw parallels with changes that occur in normal ageing and discuss the initiating cells and signalling mechanisms involved. We suggest that attempting to maintain or restore CBF should be a central aim of therapeutic strategies.