Therapeutic Antibodies 2008th Edition by Yuti Chernajovsky, Ahuva Nissim ISBN 3540732586 9783540732587 by Yuti Chernajovsky, Ahuva Nissim 3540732586 instant download after payment.

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ISBN 10: 3540732586 
ISBN 13: 9783540732587
Author: Yuti Chernajovsky, Ahuva Nissim

Therapeutic Antibodies 2008th Table of contents:

I. Fundamentals of Antibody Biology and Production

• Chapter 1: Basic Antibody Structure and Function
  • (Immunoglobulin classes, domains, binding mechanisms, effector functions)
• Chapter 2: Hybridoma Technology and Monoclonal Antibody Production
  • (Historical overview, methods for generating murine mAbs)
• Chapter 3: Recombinant Antibody Technology
  • (Phage display, yeast display, ribosome display, synthetic libraries)
• Chapter 4: Humanization and Chimerization Strategies
  • (Reducing immunogenicity: chimeric, humanized, and fully human antibodies)
• Chapter 5: Transgenic Animal Models for Human Antibody Production
  • (Mice, chickens, and other systems engineered to produce human antibodies)
• Chapter 6: Antibody Engineering: Formats and Modifications
  • (Fab fragments, scFv, bispecific antibodies, antibody-drug conjugates (ADCs), Fc engineering)
• Chapter 7: Production and Purification of Therapeutic Antibodies
  • (Cell line development, bioreactors, downstream processing, quality control)

II. Mechanisms of Action and Pharmacokinetics

• Chapter 8: Direct Mechanisms of Action: Neutralization and Receptor Blockade
  • (Blocking ligand-receptor interactions, inhibiting enzyme activity)
• Chapter 9: Effector Functions: ADCC, CDC, and Phagocytosis
  • (Antibody-dependent cell-mediated cytotoxicity, complement-dependent cytotoxicity, opsonization)
• Chapter 10: Immunogenicity of Therapeutic Antibodies
  • (Factors influencing anti-drug antibody (ADA) formation, clinical implications)
• Chapter 11: Pharmacokinetics and Pharmacodynamics of Antibodies
  • (Absorption, distribution, metabolism, excretion, half-life, target engagement)

III. Clinical Applications of Therapeutic Antibodies

• Chapter 12: Antibodies in Oncology
  • (Targeting cancer cells, immune checkpoint inhibitors, ADCs, radioimmunotherapy, bispecific antibodies for cancer)
• Chapter 13: Antibodies in Autoimmune and Inflammatory Diseases
  • (Targeting cytokines, immune cells, adhesion molecules)
• Chapter 14: Antibodies in Infectious Diseases
  • (Neutralizing toxins, antiviral antibodies, antimicrobial antibodies)
• Chapter 15: Antibodies in Cardiovascular Diseases
  • (Targeting cholesterol, coagulation factors)
• Chapter 16: Antibodies in Neurological Disorders
  • (Targeting amyloid-beta, alpha-synuclein, inflammatory mediators in CNS)
• Chapter 17: Antibodies in Organ Transplantation and Graft-versus-Host Disease
  • (Immunosuppression and modulation of immune responses)
• Chapter 18: Emerging Applications and Novel Targets
  • (Gene therapy, gene editing, ophthalmology, rare diseases)

IV. Regulatory Aspects and Future Perspectives

• Chapter 19: Regulatory Pathways for Antibody Therapeutics
  • (FDA, EMA, and other regulatory considerations for approval)
• Chapter 20: Biosimilars and Biobetters
  • (Development, approval, and market impact)
• Chapter 21: Challenges and Future Directions in Antibody Therapy
  • (Combination therapies, personalized medicine, new technologies)

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Tags: Yuti Chernajovsky, Ahuva Nissim, Therapeutic, Antibodies