This book is the first of its kind to cover the underlying principles and biomedical applications of thermoacoustic tomography (TAT). Written in a tutorial format, it describes the fundamentals of TAT; details advanced approaches for quantitative TAT; explores the development of several image enhancing schemes including both software and hardware approaches; examines array-based TAT systems; considers high-resolution TAT approaches and combinations of TAT with other imaging methods; addresses contrast agent-based molecular TAT; and discusses clinical applications and animal studies in the areas of brain, breast, joint, thyroid, liver and vascular imaging. It is a valuable resource for students, academics, and industry specialists, including biomedical engineers, electrical engineers, physicists and mathematicians.