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Toll like Receptors Roles in Infection and Neuropathology 1st Edition by Tammy Kielian ISBN 3642005489 9783642005480

  • SKU: BELL-2204282
Toll like Receptors Roles in Infection and Neuropathology 1st Edition by Tammy Kielian ISBN 3642005489 9783642005480
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Toll like Receptors Roles in Infection and Neuropathology 1st Edition by Tammy Kielian ISBN 3642005489 9783642005480 instant download after payment.

Publisher: Springer-Verlag Berlin Heidelberg
File Extension: PDF
File size: 6.38 MB
Pages: 191
Author: Tammy Kielian (auth.), Tammy Kielian (eds.)
ISBN: 9783642005480, 3642005489
Language: English
Year: 2009
Edition: 1

Product desciption

Toll like Receptors Roles in Infection and Neuropathology 1st Edition by Tammy Kielian ISBN 3642005489 9783642005480 by Tammy Kielian (auth.), Tammy Kielian (eds.) 9783642005480, 3642005489 instant download after payment.

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ISBN 10: 3642005489 
ISBN 13: 9783642005480
Author: Tammy Kielian

Mammalian Toll-like receptors (TLRs) were first identified in 1997 based on their homology with Drosophila Toll, which mediates innate immunity in the fly. In recent years, the number of studies describing TLR expression and function in the nervous system has been increasing steadily and expanding beyond their traditional roles in infectious diseases to neurodegenerative disorders and injury. Interest in the field serves as the impetus for this volume in the Current Topics in Microbiology and Immunology series entitled "Toll-like receptors: Roles in Infection and Neuropathology". The first five chapters highlight more traditional roles for TLRs in infectious diseases of the CNS. The second half of the volume discusses recently emerging roles for TLRs in non-infectious neurodegenerative diseases and the challenges faced in these models with identifying endogenous ligands. Several conceptual theories are introduced in various chapters that deal with the dual nature of TLR engagement and whether these signals favor neuroprotective versus neurodegenerative outcomes. This volume should be informative for both experts as well as newcomers to the field of TLRs in the nervous system based on its coverage of basic TLR biology as well as specialization to discuss specific diseases of the nervous system where TLR function has been implicated. A must read for researchers interested in the dual role of these receptors in neuroinfection and neurodegeneration.

Toll like Receptors Roles in Infection and Neuropathology 1st Table of contents:

  1. Overview of Toll-Like Receptors in the CNS – Tammy Kielian

  2. Toll-Like Receptors in Bacterial Meningitis – Uwe Koedel

  3. Toll-Like Receptors in Brain Abscess – Nilufer Esen, Tammy Kielian

  4. Toll-Like Receptors in CNS Viral Infections – Hyeon-Sook Suh, Celia F. Brosnan, Sunhee C. Lee

  5. Toll-Like Receptors in CNS Parasitic Infections – Bibhuti B. Mishra, Uma Mahesh Gundra, Judy M. Teale

  6. Toll-Like Receptors in Neurodegeneration – Trevor Owens

  7. Toll-Like Receptors in Spinal Cord Injury – Kristina A. Kigerl, Phillip G. Popovich

  8. Toll-Like Receptors in Alzheimer's Disease – Gary E. Landreth, Erin G. Reed-Geaghan

  9. Toll-Like Receptors in Multiple Sclerosis – Michael K. Racke, Paul D. Drew

  10. Toll-Like Receptors in Peripheral Nerve Injury and Neuropathic Pain – Donghoon Kim, Soojin Lee, Sung Joong Lee

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Tags: Tammy Kielian, Receptors, Roles

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