Treatmentresistant Depression Siegfried Kasper Stuart Montgomeryauth by Siegfried Kasper, Stuart Montgomery(auth.) 9781118556719, 9781119952909, 1118556712, 1119952905 instant download after payment.

Successful management of patients with treatment-resistant depression is going to require a thorough understanding of the biological basis for both the depression and its failure to respond to standard treatments. This book clearly and succinctly summarizes the latest  scientific research and its applications in clinical practice. 

 A first step is a clear definition of what constitutes treatment-resistant depression so that clinical trials and other studies are using common criteria, enabling comparison and meta-analysis of their outcomes.  The opening chapter reviews definitions and predictors of originating from different fields and discusses their usefulness in clinical practice and clinical research.  The next chapter proposes a new definition, adapting terminology from medicine. 

Biological classification requires identification of genetic risk factors: with gene variants accounting for 50% of the variance in the clinical outcomes of antidepressant treatments this is clearly a fruitful area of research.  Chapter 3 describes several genes already associated with treatment-resistant depression and, while further work is needed to translate findings into clinical recommendations, predicts that genetic prediction of TRD could became a widespread clinical reality within a few years.

Most patients with TRD will be treated pharmacologically and three chapters review the latest evidence for pharmacological best practice, including switching strategies for antidepressants, the role of antipsychotics and augmentation strategies to complement lithium. 

There are two major alternatives to pharmacotherapy: neuromodulation and psychotherapy.  The brain intervention chapter summarizes clinical research and experience with electroconvulsive therapy, transcranial magnetic stimulation, vagus nerve stimulation, deep brain stimulation and magnetic seizure therapy.  The final chapter reviews the literature pertaining to the effectiveness of various forms of psychotherapy in patients who have not responded to antidepressant pharmacotherapy, revealing that patients who have not responded to one or two trials of antidepressant medication have a 30%-50% chance of responding to a focused psychotherapy.  It proposes indications for psychotherapy in TRD and summarizes general therapeutic principles.

Content:
Chapter 1 Definitions and Predictors of Treatment?resistant Depression (pages 1–20): Daniel Souery and William Pitchot
Chapter 2 Treatment?resistant Depression (pages 21–41): Hans?Jurgen Moller, Florian Seemuller, Rebecca Schennach and Ramesh K. Gupta
Chapter 3 Genetics of Treatment?resistant Depression (pages 43–90): Chiara Fabbri, Stefano Porcelli and Alessandro Serretti
Chapter 4 Is There a Role for Switching Antidepressants in Treatment?resistant Depression? (pages 91–105): Stuart Montgomery
Chapter 5 The Role of Atypical Antipsychotics in Inadequate?response and Treatment?resistant Depression (pages 107–128): Siegfried Kasper and Elena Akimova
Chapter 6 Lithium, Thyroid Hormones and Further Augmentation Strategies in Treatment?resistant Depression (pages 129–157): Robert Hau?mann and Michael Bauer
Chapter 7 The Role of Nonpharmacological Interventions in Treatment?resistant Depression (pages 159–182): Thomas E. Schlapfer and Sarah Kayser
Chapter 8 The Role of Psychotherapy in the Management of Treatment?resistant Depression (pages 183–208): Michael E. Thase