Trypanosomatid Diseases Molecular Routes To Drug Discovery Paul M Selzereds by Paul M. Selzer(eds.) 9783527332557, 9783527670383, 3527332553, 3527670386 instant download after payment.

Content:
Chapter 1 Visceral Leishmaniasis – Current Treatments and Needs (pages 1–15): Poonam Salotra, Ruchi Singh and Karin Seifert
Chapter 2 Chemotherapy of Leishmaniasis: A Veterinary Perspective (pages 17–35): Maria Jesus Corral?Caridad and Jose Maria Alunda
Chapter 3 Pharmacological Metabolomics in Trypanosomes (pages 37–56): Darren J. Creek, Isabel M. Vincent and Michael P. Barrett
Chapter 4 Drug Design and Screening by In Silico Approaches (pages 57–79): Mattia Mori and Maurizio Botta
Chapter 5 Computational Approaches and Collaborative Drug Discovery for Trypanosomal Diseases (pages 81–102): Sean Ekins and Barry A. Bunin
Chapter 6 Interaction of Leishmania Parasites with Host Cells and its Functional Consequences (pages 103–119): Uta Schurigt, Anita Masic and Heidrun Moll
Chapter 7 Function of Glycosomes in the Metabolism of Trypanosomatid Parasites and the Promise of Glycosomal Proteins as Drug Targets (pages 121–151): Melisa Gualdron?Lopez, Paul A. M. Michels, Wilfredo Quinones, Ana J. Caceres, Luisana Avilan and Juan?Luis Concepcion
Chapter 8 Glyoxalase Enzymes in Trypanosomatids (pages 153–166): Marta Sousa Silva, Antonio E. N. Ferreira, Ricardo Gomes, Ana M. Tomas, Ana Ponces Freire and Carlos Cordeiro
Chapter 9 Trypanothione?Based Redox Metabolism of Trypanosomatids (pages 167–199): Marcelo A. Comini and Prof. Dr.med. Dr.h.c. Leopold Flohe
Chapter 10 Thiol Peroxidases of Trypanosomatids (pages 201–213): Helena Castro and Ana M. Tomas
Chapter 11 Peroxynitrite as a Cytotoxic Effector Against Trypanosoma Cruzi: Oxidative Killing and Antioxidant Resistance Mechanisms (pages 215–236): Madia Trujillo, Maria Noel Alvarez, Lucia Piacenza, Martin Hugo, Gonzalo Peluffo and Rafael Radi
Chapter 12 Selenoproteome of Kinetoplastids (pages 237–242): Alexei V. Lobanov and Vadim N. Gladyshev
Chapter 13 Replication Machinery of Kinetoplast DNA (pages 243–260): Rachel Bezalel?Buch, Nurit Yaffe and Joseph Shlomai
Chapter 14 Life and Death of Trypanosoma Brucei: New Perspectives for Drug Development (pages 261–277): Torsten Barth, Jasmin Stein, Stefan Mogk, Caroline Schonfeld, Bruno K. Kubata and Michael Duszenko
Chapter 15 Rational Selection of Anti?Microbial Drug Targets: Unique or Conserved? (pages 279–296): Boris Rodenko and Harry P. de Koning
Chapter 16 Drug Targets in Trypanosomal and Leishmanial Pentose Phosphate Pathway (pages 297–313): Marcelo A. Comini, Cecilia Ortiz and Juan Jose Cazzulo
Chapter 17 GDP?Mannose: A Key Point for Target Identification and Drug Design in Kinetoplastids (pages 315–334): Sebastien Pomel and Philippe M. Loiseau
Chapter 18 Transporters in Anti?Parasitic Drug Development and Resistance (pages 335–349): Vincent Delespaux and Harry P. de Koning
Chapter 19 Peptidases in Autophagy are Therapeutic Targets for Leishmaniasis (pages 351–364): Roderick A. M. Williams
Chapter 20 Proteases of Trypanosoma brucei (pages 365–382): Dietmar Steverding
Chapter 21 Screening Approaches Towards Trypanothione Reductase (pages 383–404): Mathias Beig, Frank Oellien, R. Luise Krauth?Siegel and Prof. Dr. Paul M. Selzer
Chapter 22 Redox?Active Agents in Reactions Involving the Trypanothione/Trypanothione Reductase?based System to Fight Kinetoplastidal Parasites (pages 405–428): Thibault Gendron, Don Antoine Lanfranchi and Elisabeth Davioud?Charvet
Chapter 23 Inhibition of Trypanothione Synthetase as a Therapeutic Concept (pages 429–443): Dr. Oliver Koch, Dr. Timo Jager, Prof. Dr.med. Dr.h.c. Leopold Flohe and Prof. Dr. Paul M. Selzer
Chapter 24 Targeting the Trypanosomatidic Enzymes Pteridine Reductase and Dihydrofolate Reductase (pages 445–472): Stefania Ferrari, Valeria Losasso, Puneet Saxena and Maria Paola Costi
Chapter 25 Contribution to New Therapies for Chagas Disease (pages 473–487): Patricia S. Doyle and Juan C. Engel
Chapter 26 Ergosterol Biosynthesis for the Specific Treatment of Chagas Disease: From Basic Science to Clinical Trials (pages 489–514): Julio A. Urbina
Chapter 27 New Developments in the Treatment of Late?Stage Human African Trypanosomiasis (pages 515–529): Cyrus J. Bacchi, Robert T. Jacobs and Nigel Yarlett