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Tumor Suppressor Par4 Structural Features Molecular Mechanisms And Function Vivek M Rangnekar

  • SKU: BELL-38222152
Tumor Suppressor Par4 Structural Features Molecular Mechanisms And Function Vivek M Rangnekar
$ 31.00 $ 45.00 (-31%)

4.8

84 reviews

Tumor Suppressor Par4 Structural Features Molecular Mechanisms And Function Vivek M Rangnekar instant download after payment.

Publisher: Springer
File Extension: PDF
File size: 11.07 MB
Pages: 333
Author: Vivek M. Rangnekar
ISBN: 9783030735715, 3030735710
Language: English
Year: 2022

Product desciption

Tumor Suppressor Par4 Structural Features Molecular Mechanisms And Function Vivek M Rangnekar by Vivek M. Rangnekar 9783030735715, 3030735710 instant download after payment.

Par-4 is a tumor suppressor protein first discovered and identified in 1993 by Dr. Vivek Rangnekar’s laboratory in prostate cancer cells undergoing apoptosis.  Par-4 (later also known as PAWR) is a naturally occurring tumor suppressor. Studies have indicated that Par-4 selectively induces apoptosis in cancer cells while leaving normal, healthy, cells unaffected. Mechanisms contributing to the cancer-selective action of Par-4 have been associated with protein kinase A activation of intracellular Par-4 in cancer cells or GRP78 expression primarily on the surface of cancer cells. Par-4 is downregulated, inactivated or mutated in diverse cancers. This first of two volumes will be the first on the market on the topic of Par-4, and will provide the opportunity for researchers to discuss the future direction of studies, broaden the scope of research, and contribute a more complete understanding of the molecule’s structural features, key functional domains, regulation and relevant basic and clinical/translational facets.

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