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Tuning Autophagyinducing Activity And Toxicity For Lanthanide Nanocrystals Yunjiao Zhang

Name: Tuning Autophagyinducing Activity And Toxicity For Lanthanide Nanocrystals Yunjiao Zhang
SKU: BELL-37673946
Price: 31.00 USD
Availability: InStock
Rating: 4.25 (78 reviews)

SKU: BELL-37673946

$ 31.00 ~~$ 45.00~~ (-31%)

4.3

78 reviews

Tuning Autophagyinducing Activity And Toxicity For Lanthanide Nanocrystals Yunjiao Zhang instant download after payment.

Publisher: Springer Nature

File Extension: PDF

File size: 5.27 MB

Pages: 156

Author: Yunjiao Zhang

ISBN: 9789811681660, 981168166X

Language: English

Year: 2022

Product desciption

Tuning Autophagyinducing Activity And Toxicity For Lanthanide Nanocrystals Yunjiao Zhang by Yunjiao Zhang 9789811681660, 981168166X instant download after payment.

This thesis presents a simple, yet highly effective surface engineering solution that uses non-covalent binding peptides to control the autophagy-inducing activity of nanomaterials and nanodevices. The author presents RE-1, a short synthetic peptide that sequence-specifically binds to lanthanide (LN) oxide and upconversion nanocrystals with high affinity, which was discovered using an innovative phage display approach. RE-1 effectively inhibits the autophagy-inducing activity and toxicity of these nanocrystals by forming a stable coating layer on the surface of the nanoparticles, and by reducing their sedimentation and cell interaction. RE- 1 and its variants provide a versatile tool for tuning cell interactions in order to achieve the desired level of autophagic response and are useful for the various diagnostic and therapeutic applications of LN-based nanomaterials and nanodevices.