Ultrashort Electric Pulse Effects In Biology And Medicine Stephen J Beebe by Stephen J. Beebe, Ravi Joshi, Karl H. Schoenbach, Shu Xiao 9789811051128, 9789811051135, 9811051127, 9811051135 instant download after payment.

The effects of intense electrical pulses on cell membranes have been studied extensively since the second half of the twentieth century, and have found multiple applications, ranging from bacterial decontamination to medical therapies. The first studies on this effect, named electroporation, rarely extended beyond microsecond pulse effects on cells. In the past two decades, however, the use of nanosecond and even shorter pulses gained interest, since electrical circuit models of biological cells indicated that not only the plasma membrane, but also the subcellular
structures of mammalian cells could be affected by such extremely short pulses. The first experimental study published in 2001 confirmed this hypothesis. It was followed by a large number of publications which showed that such ultrashort, high electric field, but low electrical energy pulses, affect cell functions, such as programmed cell
death, and a lower intensity, calcium mobilization from intracellular structures. This chapter, after a short introduction to electroporation, provides an overview of the progress of basic studies on nano- and picosecond pulse effects on cells, tissues, and organisms over the past two decades.