Vanilloid Receptor Trpv1 In Drug Discovery Targeting Pain And Other Pathological Disorders Arthur Gomtsyan by Arthur Gomtsyan, Connie R. Faltynek 9780470175576, 9780470588284, 0470175575, 0470588284 instant download after payment.

TRPV1 is considered an integrator of noxious stimuli and therefore may be at a crossroads for pain transmission pathways. Because of its potential for managing multiple pain types, including osteoarthritis, chronic low back pain, neuropathic pain, and cancer pain, some consider it "the holy grail" of pain management. This dedicated reference summarizes available data related to the potential therapeutic utility for TRPV1 ligands.

With contributions from many of the world's leading experts on TRP channels, Vanilloid Receptor TRPV1 in Drug Discovery covers the important TRPV1 target for drugs to treat painful conditions such as inflammation, arthritis, and cancer pain. The book discusses:

• Recent advances in biology, chemistry, and pharmacology at both the preclinical and clinical stage of the dynamic area of TRPV1 drug discovery research

• The potential for drugs targeting TRPV1 in painful conditions such as inflammation, arthritis, and cancer

• The development of analgesic drugs

• Other applications for TRPV1, including the treatment of respiratory disease and diabetes

Featuring data relevant to the therapeutic potential of TRPV1 and the medicinal chemistry involved in designing TRPV1 antagonists, Vanilloid Receptor TRPV1 in Drug Discovery is a key tool for researchers in the pharmaceutical industry and academia involved in pain, ion channels, and analgesic drug development.Content:
Chapter 1 TRP Channels and Human Diseases (pages 1–67): Bernd Nilius and Rudi Vennekens
Chapter 2 Role of TRP Channels in Pain: An Overview (pages 68–100): Arpad Szallasi
Chapter 3 Biochemical Pharmacology of TRPV1: Molecular Integrator of Pain Signals (pages 101–133): Carol S. Surowy, Philip R. Kym and Regina M. Reilly
Chapter 4 TRPV1 Genetics (pages 134–149): Ruslan Dorfman, Hubert Tsui, Michael W. Salter and H.?Michael Dosch
Chapter 5 TRPV1 and Inflammatory Pain (pages 151–174): Anindya Bhattacharya, Sonya G. Lehto and Narender R. Gavva
Chapter 6 Role of TRPV1 Receptors in Osteoarthritic Pain (pages 175–190): Shailen K. Joshi and Prisca Honore
Chapter 7 TRPV1 and Bone Cancer Pain (pages 191–205): Juan Miguel Jimenez?Andrade and Patrick Mantyh
Chapter 8 TRPV1 in Visceral Pain and Other Visceral Disorders (pages 206–238): Antonio Avelino and Francisco Cruz
Chapter 9 TRPV1 Receptors and Migraine (pages 239–259): Philip R. Holland and Peter J. Goadsby
Chapter 10 TRPV1 in Neuropathic Pain and Neurological and Neuropsychiatric Disorders (pages 260–292): Enza Palazzo, Katarzyna Starowicz, Sabatino Maione and Vincenzo Di Marzo
Chapter 11 Aryl?Urea Class and Related TRPV1 Antagonists (pages 293–310): Arthur Gomtsyan
Chapter 12 2?Pyridinylpiperazine Carboxamide Class and Related TRPV1 Antagonists (pages 311–324): Natalie A. Hawryluk and Nicholas I. Carruthers
Chapter 13 TRPV1 Agonist Approaches for Pain Management (pages 325–347): Keith R. Bley
Chapter 14 The TRPV1 Channel in Normal Thermoregulation: What Have We Learned from Experiments Using Different Tools? (pages 349–402): Andras Garami, Maria C. Almeida, Tatiane B. Nucci, Tamara Hew?Butler, Renato N. Soriano, Eszter Pakai, Kazuhiro Nakamura, Shaun F. Morrison and Andrej A. Romanovsky
Chapter 15 The Role of TRPV1 in Respiratory Diseases (pages 403–422): Serena Materazzi, Alain Tchoimou, Romina Nassini, Marcello Trevisani and Pierangelo Geppetti
Chapter 16 The Role of TRPV1 in Diabetes (pages 423–448): Hubert Tsui, Ruslan Dorfman, Michael W. Salter and H.?michael Dosch