Vascular Surgery In Oncology 1st Antonio Eduardo Zerati Editor by Antonio Eduardo Zerati (editor), Kenji Nishinari (editor), Nelson Wolosker (editor) 9783030976866, 3030976866 instant download after payment.

From a biological perspective, the vascular phase of cancers is critical for tumor
progression, as pioneering studies by Judah Folkman and his alumni demonstrated.
The interaction of tumor cells with the vascular system, either through cooption of
already-formed vascular structures or the ability of both tumor and microenvironmental
cells to induce angiogenesis, allows the integration of cancer with virtually
all systems of the organism – for good or for bad.
While it is through a functional vascular system that drugs or immune cells cantarget tumors, it is through dysfunctional vascularization that cancer cells are
exposed to an intermittent state of hypoxia followed by reoxygenation, favoring
DNA damage, mutations, and increased cancer cell genomic instability. Tumors
represent barriers to regular blood flow and interfere with lymph circulation, often
releasing cell debris which stimulates thrombotic phenomena. Different particles
released by tumor cells into circulation subvert the immune system and allow the
formation of premetastatic niches. These processes culminate in the metastatic
spread which ultimately is responsible for three out of four cancer patients’ death.
Maintaining a functional or normalized vascular system is not a simple task.
However, it is a most needed one. This is just one of the challenges that our colleagues
in vascular surgery embrace when applying their expertise in the management
of a cancer patient.
This is a book to read and to keep as a reference. Hopefully, other books like thiswill come along and provide the reader with the multidisciplinary dialogue which is
essential for the best practices in oncology.