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Report on Fourth WHO Consultation – February, 2024

Background

Since 2015, the WHO has implemented a comprehensive global research strategy and preparedness plan known as the WHO R&D Blueprint for Epidemics. A centerpiece of this work is the WHO pathogen priority list which ensures research efforts are concentrated on diseases with epidemic or pandemic potential where medical countermeasures and limited or non-existent. Since November 2022, a new approach has been implemented, focusing on entire classes of viruses or bacteria rather than individual pathogens. Around 200+ scientists from 53 countries are independently evaluating the evidence related to 30 viral families, one core group of bacteria, and “Pathogen X” – an unknown pathogen with the potential to trigger a severe global epidemic. This new approach will also help identify representative viruses (or prototypes) within a viral family as a pathfinder in generating evidence and filling knowledge gaps that may then apply to other viruses of threat in the same family.

Improved pandemic preparedness could be achieved by proactively managing emerging virus threats focused on four discreet activities using currently available tools:

- discovery and surveillance,

- targeted basic research,

- translational research and product development, and

- clinical trial infrastructure and deployment capacity.