Thalamocortical Dysrhythmiarelated Sleep Spindle Desynchronization In Patients With Tinnitus Xiaoyu Bao by Xiaoyu Bao, Xueji Feng, Et Al instant download after payment.

A B S T R A C TKeywords:Patients with tinnitus commonly suffer from sleep problems, and the underlying neural mechanisms remainTinnitusunclear. Previous studies have focused primarily on the correlation between patients’ sleep structure andSleeptinnitus, lacking exploration into the links between sleep problems and the underlying pathological mechanismsSleep spindlesof tinnitus, such as thalamocortical dysrhythmia (TCD). Here, we present the first study on neural oscillatoryThalamocortical dysrhythmiapatterns in patients with tinnitus during sleep spindles, a more precise subdivision of sleep that overlapsEEGin neuropathological pathways with TCD. Sleep electroencephalogram (EEG) were recorded from 51 tinnitusparticipants and 51 healthy participants. During sleep spindles, patients with tinnitus exhibited a significantincrease in 18–45 Hz and a stronger cross-frequency coupling, resembling the EEG abnormalities caused by TCDduring wakefulness. With respect to spindle characteristics, tinnitus is linked to an increase in spindle quantitybut a decrease in spindle root-mean-square and functional connectivity, suggesting that normal function oftinnitus spindles is impaired. Our findings indicated that neural oscillation dynamics related to TCD duringsleep spindles serve as neural biomarkers for sleep disturbances in tinnitus participants. We demonstrate thatthe impact of the TCD pathological mechanism in tinnitus is not confined to the waking state but extends intothe sleep stage as well, which advances our comprehension of the neural mechanisms underlying sleep-relatedproblems in tinnitus.