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ISBN 10: 0123814294
ISBN 13: 978-0123814296
Author: Saverio Bettuzzi, Sabina Pucci
The biological function of clusterin (CLU, also known as ApoJ, SGP2, TRPM2, CLI) has been puzzling researchers since its discovery and characterization in the early 1980s. Approaches such as cloning, expression and functional characterization of the different protein products generated by the CLU gene have now produced a critical mass of information of tremendous biological importance that are teaching us an important lesson in molecular biology of gene expression regulation. This volume brings together the contributions of top researchers in the field, providing an overview and synthesis of the latest thought and findings relating to CLU.
Front Cover
Advances in Cancer Research
Copyright
Contents
Contributors
Chapter 1: Clusterin (CLU) and Prostate Cancer
Chapter 2: The Role of Clusterin (CLU) in Malignant Transformation and Drug Resistance in Breast Car
Chapter 3: CLU and Colon Cancer. The Dual Face of CLU: From Normal to Malignant Phenotype
Chapter 4: Clusterin (CLU) and Lung Cancer
Chapter 5: Clusterin and Chemoresistance
Chapter 6: CLU "In and Out": Looking for a Link
Chapter 7: Regulation of CLU Gene Expression by Oncogenes and Epigenetic Factors
Chapter 8: Conclusions and Perspectives
Index
Color Plate
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Tags: Saverio Bettuzzi, Sabina Pucci, Advances, Cancer, Research, Part B, Volume 105
