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ISBN 10: 0123747724
ISBN 13: 978-0123747723
Author: Saverio Bettuzzi, Sabina Pucci
The biological function of clusterin (CLU, also known as ApoJ, SGP2, TRPM2, CLI) has been puzzling researchers since its discovery and characterization in the early 1980s. Approaches such as cloning, expression and functional characterization of the different protein products generated by the CLU gene have now produced a critical mass of information of tremendous biological importance that are teaching us an important lesson in molecular biology of gene expression regulation. This volume brings together the contributions of top researchers in the field, providing an overview and synthesis of the latest thought and findings relating to CLU.
Series Editors
Copyright Page
Contents
Contributors to Volume 104
Chapter 1: Introduction
Chapter 2: Clusterin (CLU): From One Gene and Two Transcripts to Many Proteins
Chapter 3: The Shifting Balance Between CLU Forms During Tumor Progression
Chapter 4: Regulation of Clusterin Activity by Calcium
Chapter 5: Nuclear CLU (nCLU) and the Fate of the Cell
Chapter 6: The Chaperone Action of Clusterin and Its Putative Role in Quality Control of Extracellular Protein Folding
Chapter 7: Cell Protective Functions of Secretory Clusterin (sCLU)
Chapter 8: Clusterin: A Multifacet Protein at the Crossroad of Inflammation and Autoimmunity
Chapter 9: Oxidative Stress in Malignant Progression: The Role of Clusterin, A Sensitive Cellular Biosensor of Free Radicals
Index
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Tags: Saverio Bettuzzi, Sabina Pucci, Advances, Cancer Research, Volume 104
