Biocatalysis For The Pharmaceutical Industry Discovery Development And Manufacturing Junhua Alex Tao by Junhua (alex) Tao, Guo-qiang Lin, Andreas Liese 9780470823149, 9780470823163, 0470823143, 047082316X instant download after payment.

• Covers a wide range of topics in a systematic manner with an emphasis on industrial applications
• Provides a thorough introduction to the latest biocatalysts, modern expression hosts, state-of-the-art directed evolution, high throughput screening, and bioprocess engineering
• Addresses frontier subjects such as emerging enzymes, metabolite profiling, combinatorial biosynthesis, metabolic engineering, and autonomous enzymes for the synthesis and development of chiral molecules, drug metabolites, and semi-synthetic medicinal compounds and natural product analogs
• Highlights the impact of biocatalysis on green chemistry
• Contains numerous graphics to illustrate concepts and techniques

Biocatalysis for the Pharmaceutical Industry is an essential resource for scientists, engineers, and R&D policy makers in the fine chemical, pharmaceutical, and biotech industries. It is also an invaluable tool for academic researchers and advanced students of organic and materials synthesis, chemical biology, and medicinal chemistry.Content:
Chapter 1 Enzymes and Their Synthetic Applications: An Overview (pages 1–19): Junhua (Alex) Tao and Jian?He Xu
Chapter 2 Expression Hosts for Enzyme Discovery and Production (pages 21–44): Aleksandra Andryushkova and Anton Glieder
Chapter 3 Directed Enzyme Evolution and High?Throughput Screening (pages 45–64): Michael J. McLachlan, Ryan P. Sullivan and Huimin Zhao
Chapter 4 Applications of Reaction Engineering to Industrial Biotransformations (pages 65–88): Lutz Hilterhaus and Andreas Liese
Chapter 5 Chiral Synthesis of Pharmaceutical Intermediates Using Oxynitrilases (pages 89–109): Wen?Ya Lu and Guo?Qiang Lin
Chapter 6 Expanding the Scope of Aldolases as Tools for Organic Synthesis (pages 111–119): William A. Greenberg
Chapter 7 Synthetic Applications of Ketoreductases and Alcohol Oxidases (pages 121–151): Dunming Zhu and Ling Hua
Chapter 8 Applications of Nitrile Hydratases and Nitrilases (pages 153–181): Grace DeSantis and Robert DiCosimo
Chapter 9 Biosynthesis of Drug Metabolites (pages 183–211): Wenying Li, David Rozzell, Spiros Kambourakis and Martin Mayhew
Chapter 10 Application of Whole?Cell Biotransformation in the Pharmaceutical Industry (pages 213–227): Kin Sing Lam
Chapter 11 Combinatorial Biosynthesis of Pharmaceutical Natural Products (pages 229–245): Wen Liu and Yi Yu
Chapter 12 Metabolic Engineering for the Development and Manufacturing of Pharmaceuticals (pages 247–271): Dongping Lu, Philip G. Williams and Guangyi Wang
Chapter 13 Multimodular Synthases and Supporting Enzymes for Chemical Production (pages 273–303): Michael Burkart and Junhua (Alex) Tao
Chapter 14 Green Chemistry with Biocatalysis for Production of Pharmaceuticals (pages 305–321): Oliver May