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Coronaviruses Advances in Experimental Medicine and Biology 1st Edition by Michael Lai, Stephen Stohlman 0306426722 9780306426728

  • SKU: BELL-216858820
Coronaviruses Advances in Experimental Medicine and Biology 1st Edition by Michael Lai, Stephen Stohlman 0306426722 9780306426728
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Coronaviruses Advances in Experimental Medicine and Biology 1st Edition by Michael Lai, Stephen Stohlman 0306426722 9780306426728 instant download after payment.

Publisher: Springer
File Extension: PDF
File size: 53.5 MB
Author: Michael M. C. Lai & Stephen A. Stohlman
Language: English
Year: 2012

Product desciption

Coronaviruses Advances in Experimental Medicine and Biology 1st Edition by Michael Lai, Stephen Stohlman 0306426722 9780306426728 by Michael M. C. Lai & Stephen A. Stohlman instant download after payment.

Coronaviruses Advances in Experimental Medicine and Biology 1st Edition by Michael Lai, Stephen Stohlman - Ebook PDF Instant Download/Delivery: 0306426722, 9780306426728

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Product details:

ISBN 10: 0306426722

ISBN 13: 9780306426728

Author: Michael M. C Lai, Stephen A Stohlman

Coronaviruses have emerged during the past ten years from being a group of viruses causing a variety of minor veterinary and human diseases to a major virus group of both clinical significance and molecular biological interest. Against this background, two international coronavirus symposia were held in 1980 and 1983. In recent years, the pace of coronavirus research has been quickened even more by infusion of recombinant DNA technology and establishment of various animal model systems to study the pathogenesis and immunology of coronavirus infections. We therefore organized the Third International Coronavirus Symposium held at Asilomar, California in September 1986, which was attended by more than 120 participants representing a cross section of both academia and industry. This symposium provided an exciting and stimulating forum for assessing the progress made since the last triennial symposium in Netherlands and to suggest the directions for future efforts. This volume collects the scientific papers presented in this symposium. Three loosely defined areas, Molecular biology, Virus-Cell Interaction and Viral Pathogenesis, are separated. These papers very nicely summarize the current status of coronavirus research. They contain a large amount of sequence data, including the complete sequence of a 27 Kb coronavirus genome, a novel mechanism of mRNA synthesis that is unique to coronviruses, and many exciting aspects of coronavirus pathogenesis and immunology. Reflecting the growing interest in the preparation of vaccines, several papers also address the issues related to coronavirus vaccines, which is an area new to this symposium. Dr."

Table of contents:

  1. Coronaviruses: A Historical Perspective

  2. Molecular Biology of Coronavirus 1986

  3. The Complete Nucleotide Sequence of Avian Infectious Bronchitis Virus: Analysis of the Polymerase-Coding Region

  4. Sequence and Structure of the Coronavirus Peplomer Protein

  5. Identification of the Coronavirus MHV-JHM mRNA 4 Gene Product Using Fusion Protein Antisera

  6. Identification of a New Gene Product Encoded by mRNA D of Infectious Bronchitis Virus

  7. Expression of Porcine Transmissible Gastroenteritis Virus Genes in E. Coli as β-Galactosidase Chimaeric Proteins

  8. Sequences Involved in the Replication of Coronaviruses

  9. Murine Coronavirus 5′-End Genomic RNA Sequence Reveals Mechanism of Leader-Primed Transcription

  10. Expression of the E1 Gene of Mouse Hepatitis Virus (MHV A59) In Vivo and In Vitro

  11. RNA Recombination of Coronavirus

  12. Surface Glycoproteins of Transmissible Gastroenteritis Virus: Functions and Gene Sequence

  13. Nucleotide Sequence of the Porcine Transmissible Gastroenteritis Coronavirus Matrix Protein Gene

  14. Deduced Amino Acid Sequence and Potential O-Glycosylation Sites for the Bovine Coronavirus Matrix Protein

  15. Glycosylation of the Bovine Coronavirus Hemagglutinin Protein

  16. Studies into the Mechanism of MHV Transcription

  17. Expression of IBV Spike Protein by a Vaccinia Virus Recombinant

  18. Translation and Processing of MHV-A59 Virion RNA in Reticulocyte Lysates and Infected Cells

  19. Temporal Regulation of RNA Synthesis of Bovine Coronavirus

  20. Temperature-Sensitive Mutants of MHV-A59

  21. Characterization of a Small Plaque Mutant of the A59 Strain of Mouse Hepatitis Virus Defective in Cell Fusion

  22. The Role of Protease-Dependent Cell Membrane Fusion in Persistent and Lytic Infections of Murine Hepatitis Virus

  23. Defective Interfering Particles of Coronavirus

  24. Identification of a Receptor for Mouse Hepatitis Virus

  25. Analysis and Pathogenetic Significance of Class II MHC (Ia) Antigen Induction on Astrocytes During JHM Coronavirus Infection in Rats

  26. Expression of MHC Class I Genes in Mouse Hepatitis Virus (MHV-A59) Infection and in Multiple Sclerosis

  27. In Vivo and In Vitro Models of Demyelinating Diseases, XX: Replication of Coronaviruses in Primary Neural Cultures from Genetically Resistant and Susceptible Mice

  28. Differential Effects of MHV-4 Infection of Astrocytes and Oligodendrocytes in Vitro

  29. In Vivo and In Vitro Models of Demyelinating Disease XXI: Relationship Between Differentiation of RAT Oligodendrocytes and Control of JHMV Replication

  30. Characterization of a Non-Pathogenic MHV3 Variant Derived from a Persistently Infected Lymphoid Cell Line

  31. Are Differences in Biological Properties of MHV Associated with Differences in Specific Regions of their Nucleocapsid mRNA?

  32. Influence of the Cell Cycle on the Infectious Titer of Murine Hepatitis Virus, Strain A59

  33. Characterization of Temperature-Sensitive Mutants Mouse Hepatitis Virus Type 3

  34. A Cell Line Defective in Murine Coronavirus Internalization

  35. Regulation of Persistent Infections with Human Coronavirus OC43

  36. Development of Rapid Assay for Screening Compounds for Antiviral Activity Against RNA Viruses

  37. Biology of Coronaviruses 1986

  38. Molecular Determinants of CNS Virulence of MHV-4

  39. Maternal Antibody-Modulated MHV-JHM Infection in C57BL/6 and BALB/c Mice

  40. Coronavirus JHM Induced Demyelinating Disease: Specific Domains on the E2-Protein are Associated with Neurovirulence

  41. Increased Hepatotropism of Mutants of MHV, Strain JHM, Selected with Monoclonal Antibodies

  42. Pathogenic Characteristics of Neutralization-Resistant Variants of JHM Coronavirus (MHV-4)

  43. Characterization of JHMV Variants Isolated from RAT Brain and Cultured Neural Cells after Wild Type JHMV Infection

  44. Critical Epitopes in Transmissible Gastroenteritis Virus Neutralization

  45. Protective Effect of the F(ab′)2 Fragments of Monoclonal Antibodies to Mouse Hepatitis Virus

  46. Intrathecal Humoral Immune Response in Corona Virus Induced Encephalo-Myelitis of Lewis and BN Rats

  47. In Vivo and In Vitro Models of Demyelinating Disease, XXIII: Infection by JHM Virus of Athymic Rats

  48. Characterization of Mouse Hepatitis Virus-Reactive T Cell Clones

  49. Immune Mediated Clearance of JHM Virus from the Central Nervous System

  50. Susceptibility to Mouse Hepatitis Virus Strain 3 in Balb/cJ Mice: Failure of Immune Cell Proliferation and Interleukin 2 Production

  51. Coronavirus and Multiple Sclerosis: Results of a Case/Control Longitudinal Serological Study

  52. Selective Tropism of MHV3 for CNS Cells and Consequences of MHV3 Infection on CNS Cells Activities

  53. Neuropathogenicity of Mutant Strains of Mouse Hepatitis Virus, 1a and 2c, from DBT Cells Persistently Infected with JHM Strain

  54. Coronavirus SD-Induced Immunoregulatory Disturbances in a Murine Model of Demyelination

  55. Intranasal Challenge Immunity of Mice to Antigenically Homologous and Heterologous Strains of Mouse Hepatitis Virus

  56. Infection and Involution of Mouse Thymus by MHV-4

  57. Genetically-Determined Sensitivity to MHV3 Infections is Expressed in Vitro in Lymphoid Cells and Macrophages

  58. Prostaglandin E2 (PGE2) Alters the Pathogenesis of MHV-3 Infection in Susceptible Balb/cJ Mice

  59. Effect of Cyclosporin A on MHV3-Induced Chronic CNS Infection in Mice

  60. Resistance to Murine Hepatitis Virus Strain 3 (MHV-3) Infection in A/J Mice is not Affected by Cyclosporin A (CSA)

  61. Monoclonal Antibodies to Two Bovine Coronavirus Glycoproteins Neutralize Virus Infectivity

  62. Antibody Response in Swine to Individual Transmissible Gastroenteritis Virus (TGEV) Proteins

  63. The Neutralization Epitopes on the Spike Protein of Infectious Bronchitis Virus and their Antigenic Variation

  64. Complement-Dependent Neutralization of Transmissible Gastroenteritis Virus by Monoclonal Antibodies

  65. Properties of Coronavirus IBV After Removal of the S1 Subunit of the Spike Glycoprotein

  66. Identification of Epitopes of Immunological Importance on the Peplomer of Porcine Transmissible Gastroenteritis Virus

  67. Characterization of Monoclonal Antibodies to Human OC43

  68. Relatedness of Rabbit Coronavirus to Other Coronaviruses

  69. Virologic and Immunologic Aspects of Feline Infectious Peritonitis Virus Infection

  70. Strategies for a Successful Coronavirus (TGE) Vaccine for Swine

  71. Humoral Immune Response of Cats to Virulent and Avirulent Feline Infectious Peritonitis Virus Isolates

  72. Immunization Against Feline Coronaviruses

  73. Serodiagnosis of Feline Infectious Peritonitis

  74. An Eight-Year Study of the Viral Agents of Acute Gastroenteritis in Humans

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Tags: Michael Lai, Stephen Stohlman, Coronaviruses, Experimental

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