Functional Neuroanatomy of Pain 1st Edition by K G Usunoff, A Popratiloff, Oliver Schmitt, Andreas Wree ISBN 3540281622 9783540281627 by K.g. Usunoff, A. Popratiloff, Oliver Schmitt, Andreas Wree 3540281622 instant download after payment.

Functional Neuroanatomy of Pain 1st Edition by K G Usunoff, A Popratiloff, Oliver Schmitt, Andreas Wree  - Ebook PDF Instant Download/Delivery: 3540281622, 9783540281627
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ISBN 10: 3540281622 
ISBN 13: 9783540281627
Author: K G Usunoff, A Popratiloff, Oliver Schmitt, Andreas Wree 

Functional Neuroanatomy of Pain 1st Table of contents:

Part I: Basic Principles and Peripheral Nociception

• Chapter 1: Defining Pain and Its Neuroanatomical Study
  • What is Pain? (IASP definition, subjective experience)
  • Dimensions of Pain: Sensory-Discriminative, Affective-Motivational, Cognitive-Evaluative
  • Historical Overview of Pain Neuroanatomy
  • Modern Approaches to Studying Pain Pathways (Neuroimaging, Electrophysiology, Molecular Biology)
• Chapter 2: Nociceptors: The Peripheral Sentinels
  • Types of Nociceptors (Thermal, Mechanical, Chemical, Polymodal)
  • Molecular Mechanisms of Nociceptor Activation (Ion Channels, Receptors)
  • Sensitization of Nociceptors: Peripheral Sensitization
  • Silent Nociceptors and Visceral Pain
• Chapter 3: Primary Afferent Fibers and Their Properties
  • Classification of Afferent Fibers (Aδ, C fibers)
  • Conduction Velocities and Myelination
  • Innervation Patterns of Skin, Muscle, Joints, and Viscera
  • Peripheral Nerve Injury and Neuropathic Pain Origins

Part II: Spinal Cord Processing and Ascending Pathways

• Chapter 4: The Dorsal Horn: The First Synaptic Relay
  • Laminar Organization of the Spinal Cord (Rexed Laminae)
  • Synaptic Connectivity within the Dorsal Horn (Interneurons, Projection Neurons)
  • Neurotransmitters and Neuromodulators in the Dorsal Horn (Glutamate, GABA, Glycine, Peptides)
  • Gate Control Theory Revisited: Local Spinal Modulation
• Chapter 5: Ascending Pain Pathways to the Brainstem and Thalamus
  • The Spinothalamic Tract (STT): Sensory-Discriminative Pain
  • The Spinoreticular Tract: Arousal and Autonomic Responses
  • The Spinomesencephalic Tract: Descending Modulation
  • Other Ascending Pathways (Spinohypothalamic, Spinoparabrachial)
• Chapter 6: Spinal Cord Plasticity and Chronic Pain
  • Central Sensitization: Mechanisms and Consequences
  • Wind-Up and Long-Term Potentiation (LTP) in the Spinal Cord
  • Microglial and Astrocytic Involvement in Spinal Pain Processing
  • Descending Facilitation and Its Role in Chronic Pain

Part III: Brainstem and Thalamic Centers of Pain Processing

• Chapter 7: Brainstem Modulatory Systems
  • Periaqueductal Gray (PAG): The Hub of Descending Control
  • Rostral Ventromedial Medulla (RVM): On-Cells and Off-Cells
  • Locus Coeruleus and Noradrenergic Modulation
  • Raphe Nuclei and Serotonergic Modulation
  • Supraspinal Opioid Systems
• Chapter 8: Thalamic Nuclei and Their Role in Pain
  • Medial Thalamic Nuclei (MD, CM/Pf): Affective-Motivational Pain
  • Lateral Thalamic Nuclei (VPL, VPM): Sensory-Discriminative Pain
  • Thalamocortical Projections and Pain Matrix Formation
  • Role in Pain Perception and Integration

Part IV: Cortical and Subcortical Networks for Pain Experience

• Chapter 9: The Somatosensory Cortices (S1, S2)
  • Primary Somatosensory Cortex (S1): Localization and Intensity
  • Secondary Somatosensory Cortex (S2): Integration and Memory
  • Somatotopic Organization of Pain
• Chapter 10: The Insula and Anterior Cingulate Cortex (ACC)
  • Insula: Visceral Pain, Interoception, and Emotional Processing
  • ACC: Affective Component of Pain, Attention, and Response Selection
  • Their Role in Pain Matrix and Salience Network
• Chapter 11: The Prefrontal Cortex and Cognitive Modulation of Pain
  • Dorsolateral Prefrontal Cortex (dlPFC): Executive Control and Cognitive Appraisal
  • Ventromedial Prefrontal Cortex (vmPFC): Emotional Regulation and Decision-Making
  • Placebo and Nocebo Effects: Cortical Mechanisms
• Chapter 12: The Limbic System: Emotion, Memory, and Pain
  • Amygdala: Fear, Anxiety, and Aversion to Pain
  • Hippocampus: Pain Memory and Learning
  • Interactions with Pain Pathways and Chronic Pain Development
• Chapter 13: Basal Ganglia, Cerebellum, and Other Structures
  • Basal Ganglia: Motor Responses to Pain, Reward System
  • Cerebellum: Coordination of Motor Responses, Sensory Prediction
  • Hypothalamus: Autonomic and Endocrine Responses to Pain

Part V: Neuroanatomical Basis of Specific Pain Syndromes and Future Directions

• Chapter 14: Neuroanatomy of Neuropathic Pain
  • Central vs. Peripheral Neuropathic Pain
  • Ectopic Discharges, Sprouting, and Denervation Hypersensitivity
  • Cortical Reorganization in Neuropathic Pain
• Chapter 15: Neuroanatomy of Headache and Facial Pain
  • Trigeminovascular System
  • Migraine: Hypothalamus, Brainstem, and Cortical Spreading Depression
  • Trigeminal Neuralgia and Other Craniofacial Pains
• Chapter 16: Visceral Pain and Referred Pain
  • Distinct Anatomical Pathways for Visceral Nociception
  • Mechanisms of Referred Pain
  • Visceral Hypersensitivity in Chronic Pain Conditions
• Chapter 17: Phantom Limb Pain and Other Central Pain Syndromes
  • Cortical Reorganization and Maladaptive Plasticity
  • Thalamic and Spinal Cord Mechanisms
  • Central Post-Stroke Pain, Multiple Sclerosis Pain
• Chapter 18: Advanced Neuroimaging and Future Research Directions
  • fMRI, PET, MEG for Studying Pain Circuits
  • Connectomics and Network Analysis in Pain
  • Optogenetics and Chemogenetics for Causal Inference
  • Translational Research: From Bench to Bedside in Pain Management

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