GABAReceptor Pharmacology A Tribute to Norman Bowery 1st Edition by Thomas Blackburn ISBN 0123786479 9780123786470 by Thomas P. Blackburn (eds.) 978-0-12-378647-0 instant download after payment.

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ISBN 10: 0123786479 
ISBN 13: 9780123786470
Author: Thomas Blackburn

This monograph was assembled to honor Professor Norman Bowery and his work on the 30th anniversary of his discovery of the GABAB receptor. In the present volume, leading neuroscientists from academia and industry provide a perspective of current research, both basic and translational, in the discovery of drugs acting at the GABAB receptor. The topics covered provide a comprehensive review of the field and the current state of research in this area. Included are chapters on the chemistry of GABAB agonists and antagonists, on the genetics and molecular composition of the site, its regulation and trafficking, and its role in controlling cellular, autonomic, and behavioral function. There are also chapters describing the potential clinical utility of drugs regulating GABAB activity receptor in the areas of hypertension, gastroesophageal reflux disease, Down syndrome, depression, and substance abuse.

The information contained in this text will be of particular interest to neuroscientists in general and to neuropharmacologists in particular.

Articles written by leading investigators in the field
Informs and updates on all the latest developments

GABAReceptor Pharmacology A Tribute to Norman Bowery 1st Table of contents:

1. Introduction

2. GABAB Receptor Ligands

3. Receptor Distribution

4. Allosteric Modulation

5. Receptor Function

6. Potential Therapeutic Significance

7. Conclusion

8. Chemistry and Pharmacology of GABAB Receptor Ligands

9. GABAB Receptor Agonists

10. GABAB Receptor Partial Agonists

11. Positive Modulators of GABAB Receptors

12. GABAB Receptor Antagonists

13. Conclusion

14. Heterodimerization of the GABAB Receptor: Implications for GPCR Signaling and Drug Discovery

15. Identification of the GABAB Receptors

16. The Phylogeny of GABAB Receptors in Different Species

17. Structure of GABAB Receptors

18. Function of the GABAB Receptor Heterodimer

19. GABAB as a Model System for GPCR Dimerization

20. Conclusions

21. Mechanisms of GABAB Receptor Exocytosis, Endocytosis, and Degradation

22. Cell-Surface Trafficking of GABAB Receptors

23. Endocytosis of GABAB Receptors

24. Degradation of GABAB Receptors

25. Conclusions

26. Functional Modulation of GABAB Receptors by Protein Kinases and Receptor Trafficking

27. Phosphorylation of GABABR and Its Functional Modulation

28. Phosphorylation-Independent Desensitization of GABABRs by Protein Kinases

29. GABABR Endocytic Sorting and the Control of Receptor Cell Surface Stability

30. GABABR Phosphorylation and Diseases

31. Conclusion

32. GABAB Receptor Coupling to G-proteins and Ion Channels

33. GABAB Receptor Structure

34. GABAB Receptor Protein Expression

35. GABAB Receptor Effectors

36. Formation of a Macromolecular Signaling Heterocomplex

37. GABAB Receptor-Dependent Desensitization

38. Conclusion

39. GABAB Receptor-Mediated Modulation of Metabotropic Glutamate Signaling and Synaptic Plasticity in Central Neurons

40. Synaptic Organization Around Cerebellar Purkinje Cells

41. Possible Ligands for GABABR in Cerebellar Purkinje Cells

42. Functions of GABABR Near the Excitatory Synapses

43. Possible Physiological Significance of GABABR-Mediated Effects on mGluR1 Signaling

44. Conclusion

45. GABA Transporter GAT1: A Crucial Determinant of GABAB Receptor Activation in Cortical Circuits?

46. The Plasma Membrane GABA Transporter

47. Cellular and Subcellular Localization of GABABRs and GAT1

48. GABABR Activation by GABA Released from Endogenous Sources

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Tags: Thomas Blackburn, GABAReceptor, Pharmacology