Immunonutrition interactions of diet genetics and inflammation 1st Edition by Bharat B Aggarwal, David Heber ISBN 9781466503861 by Aggarwal, Bharat B(editor);heber, David 9781466503854, 9781466503861, 1466503858, 1466503866 instant download after payment.

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ISBN 13: 9781466503861
Author: Bharat B Aggarwal, David Heber

The interaction of immune function and nutrition underlies the low-grade chronic inflammation involved in the etiology of many common obesity-associated and age-related chronic disease conditions. This close interaction is the genesis of the term immunonutrition, which represents a new interdisciplinary field of nutritional and medical research. Im

Immunonutrition interactions of diet genetics and inflammation 1st Table of contents:

Chapter 1 Evolution of Innate and Adaptive Immunity
Introduction
Evolution of Innate Immunity
Innate Immune System in Plants
Innate Immune System in Humans
Evolution of Cellular Immunity
Immunity and Inflammation
Cellular Immunity
Adaptive Immune System
Malnutrition and Immune Function
Immune Function in Obesity
Macrophage Receptors for Omega-3 Fatty Acids
Immune Function and Vitamin and Mineral Balance
Practical Considerations for Modulating Immune Function
References
Chapter 2 Cellular Mechanisms of Cytokine Activation
Introduction
Transcription Factors and Mitogen-Activated Kinase Pathways
Nuclear Factor-Kappa B
Nuclear Factor of Activated T-Cells
ActivatingProtein-1
Extracellular Signal–Regulated Kinases
c-Jun N-Terminal Kinases
p38
Reactive Oxygen Species and Immune Function
Lipid Peroxidation Products
Cytokine Activation Pathways
Inflammasome, Cytokines, and Pyroptosis
Conclusion
References
Chapter 3 Cellular Lipids and Inflammation
Introduction
Fat as an Essential Macronutrient
Relationship of Excess Fat Calories and Visceral Fat to Inflammation
Subcellular Signaling Pathways Linking Inflammation and Metabolism
Eicosanoids
Lipid Rafts and Cellular Signaling
Conclusion
References
Chapter 4 Biomarkers of Inflammation and the Western Diet
Introduction
Mechanisms Underlying Chronic Low-Grade Inflammation
C-Reactive Protein and Other Acute-Phase Reactants
Proinflammatory Cytokines
Chemokines
Telomere Length
Adiponectin
Vitamin D and Inflammation
Conclusion
References
Chapter 5 Phytochemicals and Immune Function
Introduction
Phytochemical Evolution and Human Immunity
Classification of Phytochemicals
Phytochemicals and Inhibition of Inflammation
Tea
Berry Polyphenols and Hydrolyzable Tannins from Pomegranate
Condensed Tannins from Grape Seed Extract
Cocoa Polyphenols from Chocolate
Glucosinolates
Carotenoids
Conclusions and Future Directions
References
Chapter 6 Genetic and Environmental Modifiers of Immune Function
Introduction
Genetic Variation in Complex Diseases
Genetic Variation in the Immune System
Interaction of the Immune System with the Microbes in the Environment
Obese Microbiota: Interactions with the Immune System
Autoimmune Disorders and the Gut Microflora
Conclusion
References
Chapter 7 Cancer and Inflammation
Introduction
Acute Inflammation and Cancer
Chronic Inflammation and Cancer
Colon Cancer and Gut Microflora
Helicobacter and Stomach Cancer
Hepatitis Viruses and Liver Cancer
Prostate Cancer and Inflammation
Inflammation and Lymphomas
Inflammation in Tumor Promotion, Angiogenesis, and Metastasis
Targeted Immunotherapy: Inflammation and Tumor Cell Killing
Inflammation as a Side Effect of Tumor Treatment
Inflammation as a Causative Factor in Cancer Cachexia
Conclusion
References
Chapter 8 Abdominal Obesity: Pathophysiology and Related Metabolic Complications
Introduction
Abdominal Obesity and Disease Risk
Metabolic Abnormalities Related to Visceral Obesity
AdiposeOrgan
Adipose Tissue Dysfunction in Obesity
Adipose Tissue Distribution
Heterogeneity among Adipose Tissue Depots
Differences in Developmental Roots of Adipose Tissue
Differences in Cellularity, Growth, and Remodeling
Differences in Adipocyte Metabolism
Theory of the Portal Circulation
Theory of Ectopic Fat Deposition
Adipokine and Cytokine Secretion
Lessons from Fat-Tissue Removal and Transplantation
Measuring Abdominal Fat in Clinical Practice
Conclusion
References
Chapter 9 Type 2 Diabetes and Inflammation
Introduction
Cytokines and Inflammation in Diabetes
Dietary Factors in Inflammation
Cellular and Subcellular Mechanisms of Inflammation in Diabetes
References
Chapter 10 Heart Disease and Inflammation
Cardiovascular Health, Systemic Inflammation, Intestine, and Oxidized Lipids
LDL Oxidized Phospholipids
HDL and Prevention of Lipid Oxidation
HDL Mimetic Peptides
Inflammatory Reaction in Vascular and Nonvascular Cells Initiated by Oxidized Lipids
Prevention of Inflammatory Reaction by HDL
Dysfunctional HDL
Small Intestine Is Important in Modulating Systemic Inflammation
Conclusion
References
Chapter 11 Chronic Kidney Disease and Inflammation
Introduction
Injury and the Initiation of Renal Inflammation
Kidney Disease and Inflammation: The Role of Macrophages
Kidney Disease and Inflammation: The Role of T-Cells
Kidney Disease and Inflammation: Proinflammatory and Proresolution Molecules
Course of Inflammation and CKD
Nutrition and Renal Inflammation: Potential Interactions
Conclusion
References
Chapter 12 Alzheimer’s Disease and Inflammation
Introduction
Overview of Pathogenesis of Alzheimer’s Disease
Overview of the Inflammatory System and AD
Anti-inflammatory Treatments
Antioxidants
Ginkgo biloba
Estrogens
Curcumin
Fatty Acids
Immunotherapy
Additional Aβ-Lowering Therapies
Summary
References
Chapter 13 Nutrition in Autoimmunity: A Focus on Systemic Lupus Erythematosus and Rheumatoid Arthritis
Introduction
Caloric Restriction
Amino Acids
Taurine
Isoflavones
n-3 and n-6 Polyunsaturated Fatty Acids
Furanocoumarins
Vitamin D
Vitamin E
Vitamins B6, B12, and Folate
Vitamin C
Curcumin
Conclusions
References
Chapter 14 Asthma and Inflammation
Introduction
Asthma: A Complex Disorder
Air Pollution
Oxidant Stress and Asthma
Nrf2 and Oxidant Stress
Cellular Mechanisms of Inflammation in Allergic Asthma
Effects of Particulate Matter in Allergic Asthma
Asthmaand Obesity
Conclusion
References
Chapter 15 Muscle and Immune Function
Introduction
Function of Myokines: Cytokines Secreted by Muscle Cells
Visceral/Subcutaneous Fat and Inflammation
Skeletal Muscle, Sarcopenia, and Inflammation
Conclusion
References
Chapter 16 Approaches to Reducing Abdominal Obesity
Introduction
Significance of Visceral Fat
Origins of Visceral Fat
Hormonal Influences on Abdominal Visceral Fat
Testosterone
Estrogen
Cortisol
Endocannabinoids
Growth Hormone
Dietary Fructose
Correcting Underlying Hormonal Abnormalities
Iatrogenic Hormones and Obesity: Insulin and Glucocorticoids
Testosterone
Growth Hormone
Exercise and Diet Interventions to Reduce Visceral Adiposity
Conclusion
References
Chapter 17 Barriers to Fruit and Vegetable Consumption and Practical Strategies for Increasing Fruit and Vegetable Intake
Introduction
Fruit and Vegetable Intakes in the US Population
Barriers to Fruit and Vegetable Consumption
Cost as a Barrier to Fruit and Vegetable Consumption
Lack of Access as a Barrier to Fruit and Vegetable Consumption
Inconvenience as a Barrier to Consumption
Taste as a Barrier to Intake
Increasing Fruit and Vegetable Consumption
Predictors of Fruit and Vegetable Intake
Addressing Barriers to Fruit and Vegetable Intake
Simple Strategies for Increasing Fruit and Vegetable Intake
References
Chapter 18 Healthy Fats and Oils: Balancing Omega-3 and Omega-6 Acids in Tissues
Introduction
Converting Dietary Fats into Tissue Lipids
Converting Tissue HUFA into Receptor-Mediated Signals
Recognizing How Nutrients Cause Harm and What Is a Valid Surrogate
Tools to Create Balanced Omega-3 and Omega-6 Acids in Tissues
Health Risk Assessment
Quantitative Link of Foods with HRA Values
Ways to “NIX the 6 and EAT the 3”
Vegetables and Fruits
Food Oils and Fats
Beans Are Legumes
Unexpected Values and Other Surprises
Key Foods for Americans
Conclusions
Acknowledgment
References
Chapter 19 Spices and Dietary Supplements with Anti-Inflammatory Activity
Introduction
History of Spices
Turmeric and Curcuminoids
Chili and Capsaicin
Ginger and Gingerol
Black Pepper and Piperine
Cinnamon and Cinnamaldehyde
Fenugreek and Parthenolide
Homologous Structures and In Vitro Antioxidant Function of Spices
Spices and In Vivo Inhibition of Lipid Oxidation
Dietary Supplements Containing Spices
Conclusion
References
Index

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Tags: Bharat B Aggarwal, David Heber, Immunonutrition, interactions