Lysophospholipid Receptors Signaling And Biochemistry Edited By Jerold Chun Timothy Hla Sara Spiegel Wouter Moolenaar by Edited By Jerold Chun Timothy Hla Sara Spiegel Wouter Moolenaar 9780470569054, 9781118531426, 0470569050, 1118531426 instant download after payment.

The study of lysophospholipids exploded with the discovery of cell surface receptors on both lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P). Since then, thousands of original research reports?ranging from fundamental cell signaling to the physiology and pathophysiology of individual organ systems?have centered on lysophospholipids. This book draws together and analyzes the current literature to provide readers with a state-of-the-science review as well as current techniques that support research in all aspects of the field of lysophospholipid signaling.

Lysophospholipid Receptors is divided into three sections:

• Receptors and other possible effectors
• Enzymes
• Physiology and pathophysiology

Within each section, the authors explain the similarities and differences between LPA and S1P signaling. Examples are provided that demonstrate the underlying mechanisms of lysophospholipid signaling across a broad range of organ systems, such as S1P signaling in cardiovascular physiology and disease and the neural effects of LPA signaling. Extensive references at the end of each chapter provide a gateway to the literature and facilitate further research into individual topics.

Each chapter has been authored by one or more leading international authorities in lysophospholipid research. Based on a thorough analysis of the current research, the authors set forth what is established science and offer their expert opinion and perspective on new and emerging areas of research, setting the stage for further investigations that will solve current problems in the field.

Content:
Chapter 1 Lysophosphatidic Acid (LPA) Receptor Signaling (pages 1–39): Hope Mirendil, Mu?En Lin and Jerold Chun
Chapter 2 Sphingosine 1?Phosphate (S1P) Receptors (pages 41–60): Bongnam Jung and Timothy Hla
Chapter 3 Global Gene Expression Program of Lysophosphatidic Acid (LPA)?Stimulated Fibroblasts (pages 61–69): Catelijne Stortelers and Wouter H. Moolenaar
Chapter 4 Identification of Direct Intracellular Ta