Peptides As Drugs Discovery And Development Bernd Groner by Bernd Groner 9783527322053, 9783527626830, 3527322051, 3527626832 instant download after payment.

By covering the full spectrum of topics relevant to peptidic drugs, this timely handbook serves as an introductory reference for both drug developers and biomedical researchers interested in pharmaceutically active peptides, presenting both the advantages and challenges associated with this molecular class.
The first part discusses current approaches to developing pharmaceutically active peptides, including case studies of the use of peptidic drugs in cancer and AIDS therapy. The second part surveys strategies for the development and targeting of peptidic drugs.
With its integration of biochemical, pharmaceutical and clinical research, this work reveals the full picture of modern peptide drug research in a single volume, making it an invaluable reference for medicinal chemists, biochemists, biotechnologists, and those in the pharmaceutical and biotechnological industries.Content:
Chapter 1 Peptides as Drugs: Discovery and Development (pages 1–8): Prof. Dr. Bernd Groner
Chapter 2 Mimics of Growth Factors and Cytokines (pages 9–34): Jurgen Scheller, Joachim Grotzinger and Stefan Rose?John
Chapter 3 Peptides Derived from Exon v6 of the CD44 Extracellular Domain Prevent Activation of Receptor Tyrosine Kinase and Subsequently Angiogenesis and Metastatic Spread of Tumor Cells (pages 35–55): Helmut Ponta and Veronique Orian?Rousseau
Chapter 4 Peptide Aptamers Targeting the Viral E6 Oncoprotein Induce Apoptosis in HPV?positive Cancer Cells (pages 57–72): Felix Hoppe?Seyler, Susanne Dymalla, Markus A. Moosmeier and Karin Hoppe?Seyler
Chapter 5 The Prevention of HIV Infection with Viral Entry Inhibitors (pages 73–102): Lisa Egerer, Anne Hubert, Dorothee von Laer and Ursula Dietrich
Chapter 6 Intracellular Expression of Peptides (pages 103–123): Christian Wichmann, Yvonne Becker and Manuel Grez
Chapter 7 The Internalization Mechanisms and Bioactivity of the Cell?Penetrating Peptides (pages 125–143): Mats Hansen, Elo Eriste and Ulo Langel
Chapter 8 Production and Purification of Monomeric Recombinant Peptide Aptamers: Requirements for Efficient Intracellular Uptake and Target Inhibition (pages 145–186): Corina Borghouts and Astrid Weiss
Chapter 9 Peptide Arrays on Solid Supports: A Tool for the Identification of Peptide Ligands (pages 187–217): Mike Schutkowski, Alexandra Thiele and Joachim Koch